More than 50% of patients with spinal metastases have multiple levels involved.
see Skull metastases
Cancer cells that break off from a primary tumor and enter the bloodstream or lymph vessels can reach nearly all tissues of the body. Bones are a common place for these cancer cells to settle and start growing. Tumors that result from these cells entering the bones are called bone metastases.
Presence of bone metastases at baseline was associated with a worse prognosis for patients with Non-Small Cell Lung Cancer treated with Immune Checkpoint Inhibitor after controlling for multiple clinical characteristics. Use of bone-modifying agents (BMAs) was not associated with reduced skeletal-related events (SREs) or a difference in survival 3).