Parasagittal Meningioma Differential Diagnosis

see also Meningioma Differential Diagnosis.

Intracerebral schwannoma ^{1) 2) 3) 4)}.

Extra-axial ependymoma ^5) 6).

Fibrous histiocytoma ⁷⁾.

Rosai-Dorfman disease ⁸⁾.

A 14-year-old female mosaic for the de novo p.R108H pathogenic variant in the PIK3CA gene was found to have a large tumor involving the superior sagittal sinus with mass effect on the motor cortex most consistent with a parafalcine meningioma. She underwent surgical resection with pathology demonstrating a venous malformation. PIK3CA pathogenic variants have been identified in nonsyndromic extracranial venous and lymphatic malformations as well in brain tumors, including glioma and meningioma. However, PIK3CA variants have not previously been identified in purely intracranial venous malformations. This distinction is relevant to treatment decisions, given that mTOR inhibitors may provide an alternative option for noninvasive therapy in cases of suspected venous malformation ⁹⁾.