Carotid Endarterectomy

Carotid Endarterectomy

The most common surgical intervention for carotid artery stenosis is carotid endarterectomy (CEA). Many studies on CEA have been reported and suggested medical indications. For symptomatic carotid artery stenosis, generally, CEA may be indicated for patients with more than 50% stenosis and is especially beneficial in men, patients aged 75 years or older, and patients who underwent surgery within 2 weeks of their last symptoms. For asymptomatic carotid artery stenosis. CEA may be indicated for those with more than 60% stenosis, though each guideline has different suggestions in detail. In order to evaluate the indication for CEA in each case, it is important to assess risks for CEA carefully including anatomical factors and comorbidities and to elaborate each strategy for each operation based on preoperative imaging studies including carotid ultrasonographymagnetic resonance imaging, and angiography. In surgery, there are many tips on operative position, procedure, shunt usage, and monitoring to perform a safe and smooth operation. Now that carotid artery stenting has been rapidly developed, a better understanding of CEA is required to treat carotid artery stenosis adequately. 1).

Carotid artery endarterectomy is widely used on the carotid artery of the neck as a way to reduce the risk of stroke, particularly when the carotid artery is narrowed by more than 70%. A carotid endarterectomy may itself cause a stroke at the time of operation.

Endarterectomy is also used as a supplement to a vein bypass graft to open up distal segments.

Pulmonary hypertension caused by chronic thromboembolic disease (CTEPH) may be amenable to pulmonary thromboendarterectomy of the pulmonary artery. This is a highly specialized procedure.

Carotid artery stenosis (CS) is a major cause of ischemic stroke. Treatment of CS consists of best medical treatment and carotid revascularization (CR), including carotid endarterectomy (CEA) and carotid artery stenting (CAS). Both CR techniques have their own procedural risks. Therefore, selection of the appropriate treatment for patients with CS is relatively complicated. Many studies and guidelines have reported the efficacy of each treatment for both symptomatic and asymptomatic patients. However, the results are still controversial, especially concerning the efficacy and safety of CEA and CAS 2).

Carotid endarterectomy is a surgical procedure to remove the atheromatous plaque material, or blockage, in the lining of an artery constricted by the buildup of soft/hardening deposits. It is carried out by separating the plaque from the arterial wall.

Atherosclerotic stenosis of the internal carotid artery causes 10–15% of all strokes. Carotid endarterectomy lowers the long-term risk of stroke in patients with symptomatic carotid artery stenosis 3) 4).

Carotid endarterectomy (CEA) is a common, well-developed surgical procedure.

Technique: Carotid endarterectomy is safe, effective, and durable, but can we make it better? 5).

Carotid artery endarterectomy indications.

Identifying patients at high risk for complications after CEA has proven challenging. Typically, the exclusion criteria from studies are cited, but in most cases, these are simply patients that were not included in the study because it was the investigators’ perception that these patients might be “high risk.” Therefore these risk factors are not validated. They are included here for completeness. NASCET and ACAS: age > 80 years, prior ipsilateral CEA, prior contralateral CEA within 4 months, prior neck XRT, tandem lesion larger than target lesion, other conditions that could cause symptoms (atrial fibrillation, prior stroke with persistent major deficit, valvular heart disease), major organ failure, uncontrolled hypertension or diabetes mellitus, and significant coronary artery disease 6) 7)

The SAPPHIRE Trial (Stenting and Angioplasty with Protection in Patients at High-Risk for Endarterectomy): patients with clinically significant cardiac disease (CHF, abnormal stress test, or need for open-heart surgery), severe pulmonary disease, contralateral carotid occlusion, contralateral laryngeal-nerve palsy, previous radical neck surgery or neck XRT, recurrent stenosis after endarterectomy, and age > 80 years 8).

The ARCHeR Trial (ACCULINK for Revascularization of Carotids in High-Risk patients) also included patients with tracheostomy, spinal immobility, and dialysis-dependant renal failure 9).

Most (but not all) surgeons monitor some parameter of neurologic function during carotid endarterectomy, and will alter technique (e.g. insert a vascular shunt) if there is evidence of hemodynamic intolerance of carotid clamping (only occurs in ≈ 1–4%).

  1. local/regional anesthesia: permits “clinical” monitoring of patient’s neurologic function 10) 11)


patient movement during procedure (often exacerbated by sedation and alterations in CBF), lack of cerebral protection from anesthetic and adjunctive agents. The only prospective randomized study found no di erence between local and general anesthesia 12). The multicenter, randomized controlled General Anesthesia versus Local Anesthesia (GALA) Trial 13) found no significant differences in the prevention of stroke, MI, or death for either anesthetic technique. Subgroup analysis showed trends (not statistically significant) favoring local anesthesia for perioperative death, event-free survival at 1 year, and patients with contralateral occlusion. Local anesthesia was associated with a significant reduction of shunt insertion 14).

A Cochrane Database Review found no evidence from randomized trials to favor either anesthetic technique 15)

  1. general anesthesia, possibly including barbiturates (thiopental boluses of 125–250 mg until 15– 30 second burst suppression on EEG, followed by small bolus injections or constant infusion to 16)

a) EEG monitoring

b) SSEP monitoring

c) measurement of distal stump pressure after CCA occlusion (unreliable), e.g. using a shunt if stump pressure <25 mm Hg

d) transcranial Doppler

e) near-infrared spectroscopy.

Both general anesthesia and local anesthesia are used in the University Hospital Pilsen for carotid endarterectomy (CEA). The decision as to which anesthetic technique to use during surgery is made individually.

The satisfaction of a group of 205 patients with regard to anesthesia used and their future preferences were evaluated prospectively through a questionnaire. The reasons for dissatisfaction were assessed.

CEA was performed under general anesthesia (GA) in 159 cases (77.6%) and under local anesthesia (LA) in 46 cases (22.4%). In the GA group, 148 patients (93.1%) were satisfied; 30 patients (65.2%) in the LA group were satisfied (p < 0.0001). The reason for dissatisfaction with GA were postoperative nausea and vomiting (7 patients), postoperative psychological alteration (3), and fear of GA (1). The reasons for dissatisfaction with LA were intraoperative pain (9 patients), intraoperative discomfort and stress (5), and intraoperative breathing problems (2). Of the GA group, 154 (96.9%) patients would prefer GA again, and of the LA group, 28 (60.9%) patients would prefer LA if operated on again (p < 0.0001). Overall, 172 patients (83.9%) would prefer GA in the future, and 33 patients (16.1%) would prefer LA.

Overall patient satisfaction with CEA performed under both GA and LA is high. Nevertheless, in the GA group, patient satisfaction and future preference were significantly higher. Both GA and LA have advantages and disadvantages for CEA. An optimal approach is to make use of both anesthetic techniques based on their individual indications and patient preference 17).

Post-op check

In addition to routine, the following should be checked:

  1. change in neurologic status due to cerebral dysfunction, including:

a) pronator drift(R/O new hemiparesis)

b) signs of dysphasia (especially for left-sided surgery)

c) mimetic muscle symmetry (assesses facial nerve function)

  1. pupil diameter and reaction (R/O stroke, Horner syndrome)

  2. severe H/A (especially unilateral) > may indicate hyperperfusion syndrome

  3. STA pulses (R/O external carotid occlusion)

  4. tongue deviation (R/O hypoglossal nerve injury)

  5. symmetry of lips (R/O weakness of lower lip depressors due to retraction of marginal mandibular branch of the facial nerve against mandible usually resolves in 6–12 wks, must differentiate from central VII palsy due to stroke)

  6. check for hoarseness (R/O recurrent laryngeal nerve injury)

  7. assess for a hematoma in operative site: note any tracheal deviation, dysphagia

A bovine placenta training model for CEA is inexpensive and readily available and closely resembles human carotid arteries. The model can provide a convenient and valuable simulation and practice addition for vascular surgery training 18).

Neurocognitive performance is used to assess multiple cognitive function, including motor coordination, before and after carotid endarterectomy (CEA).

Carotid artery endarterectomy complications.

Citation analysis on carotid endarterectomy has witnessed a marked shift in the publication trends from studying the outcome and complications to comparing carotid artery stenting with endarterectomy. This analysis is a good introductory article to physicians interested in this topic, as it summarizes the highly impactful articles and enlists the most-cited RCT on CEA 19).

Carotid artery endarterectomy case series


Hara T, Rai Y. Carotid Endarterectomy. Adv Tech Stand Neurosurg. 2022;44:187-207. doi: 10.1007/978-3-030-87649-4_10. PMID: 35107680.

Noiphithak R, Liengudom A. Recent Update on Carotid Endarterectomy versus Carotid Artery Stenting. Cerebrovasc Dis. 2016 Nov 30;43(1-2):68-75. [Epub ahead of print] PubMed PMID: 27898402.

North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991; 325: 445–53.

European Carotid Surgery Trialists’ Collaborative Group. Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST). Lancet 1998; 351: 1379–87.

Williamson RW, Spetzler RF. Carotid endarterectomy is safe, effective, and durable, but can we make it better? World Neurosurg. 2016 Jan 2. pii: S1878-8750(15)01794-5. doi: 10.1016/j.wneu.2015.12.087. [Epub ahead of print] PubMed PMID: 26752091.

Nguyen LL, Conte MS, Reed AB, et al. Carotid endarterectomy: who is the high-risk patient? Semin Vasc Surg. 2004; 17:219–223

Kang JL, Chung TK, Lancaster RT, et al. Outcomes after carotid endarterectomy: is there a high-risk population? A National Surgical Quality Improvement Program report. J Vasc Surg. 2009; 49:331–8, 339 e1; discussion 338-9

Yadav JS, Wholey MH, Kuntz RE, et al. Protected carotid-artery stenting versus endarterectomy in high- risk patients. N Engl J Med. 2004; 351:1493–1501

Gray WA, Hopkins LN, Yadav S, et al. Protected carotid stenting in high-surgical-risk patients: the ARCHeR results. J Vasc Surg. 2006; 44:258–268

Zuccarello M, Yeh H-S, Tew JM. Morbidity and Mortality of Carotid Endarterectomy under Local Anesthesia: A Retrospective Study. Neurosurgery. 1988; 23:445–450

Lee KS, Courtland CH, McWhorter JM. Low Morbidity and Mortality of Carotid Endarterectomy Performed with Regional Anesthesia. J Neurosurg. 1988; 69:483–487

Forssell C, Takolander R, Bergqvist D, et al. Local Versus Gen eral An esth esia in Carotid Surgery. A Prospect ive Randomized Study. Eur J Vasc Surg. 1989; 3:503–509
13) , 14)

Lewis SC, Warlow CP, Bodenham AR, Colam B, Rothwell PM, Torgerson D, Dellagrammaticas D, Horrocks M, Liapis C, Banning AP, Gough M, Gough MJ. General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial. Lancet. 2008; 372:2132– 2142

Rerkasem K, Rothwell PM. Local versus general anaesthesia for carotid endarterectomy. Cochrane Database Syst Rev. 2008. DOI: 1 0.1 002/1 465185 8. CD000126.pub3

Spetzler RF, Martin N, Hadley MN, et al. Microsurgical Endarterectomy Under Barbiturate Protection: A Prospective Study. J Neurosurg. 1986; 65:63–73

Mracek J, Kletecka J, Holeckova I, Dostal J, Mrackova J, Mork J, Priban V. Patient Satisfaction with General versus Local Anesthesia during Carotid Endarterectomy. J Neurol Surg A Cent Eur Neurosurg. 2019 Apr 29. doi: 10.1055/s-0039-1688692. [Epub ahead of print] PubMed PMID: 31035296.

Belykh EG, Lei T, Oliveira MM, Almefty RO, Yagmurlu K, Elhadi AM, Sun G, Bichard WD, Spetzler RF, Preul MC, Nakaji P. Carotid Endarterectomy Surgical Simulation Model Using a Bovine Placenta Vessel. Neurosurgery. 2015 Jul 30. [Epub ahead of print] PubMed PMID: 26230044.

Turki E, Almutairi OT, Modhi A, Mohammed B, Alturki AY. A bibliometric analysis on the most-cited publications on carotid endarterectomy throughout history. J Cerebrovasc Endovasc Neurosurg. 2021 Dec 2. doi: 10.7461/jcen.2021.E2021.03.010. Epub ahead of print. PMID: 34852422.

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