Idiopathic normal pressure hydrocephalus MRI

Idiopathic normal pressure hydrocephalus MRI

see Evans index

see Callosal angle

see Cingulate sulcus sign

see DESH

NPH is characterized by an ongoing periventricular neuronal dysfunction seen on MRI as periventricular hyperintensity (PVH). Clinical improvement after shunt surgery is associated with CSF changes indicating a restitution of axonal function. Other biochemical effects of shunting may include increased monoaminergic and peptidergic neurotransmission, breakdown of blood brain barrier function, and gliosis 1).

An MRI-based diagnostic scheme used in a multicenter prospective study (Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement [SINPHONI]) appears to suggest that features of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) are meaningful in the evaluation of NPH 2).

see Phase contrast magnetic resonance imaging for idiopathic normal pressure hydrocephalus.

Diffusion-weighted magnetic resonance imaging (DWI3) is used generally in the diagnosis and treatment of various neurodegenerative diseases. The apparent diffusion coefficient (ADC) of the brain, calculated from DWI data, is overestimated because of the effect of bulk motion (rigid body motion caused by the brain pulsation).

see Arterial spin labelled imaging for idiopathic normal pressure hydrocephalus.


1)

Tullberg M, Blennow K, Månsson JE, Fredman P, Tisell M, Wikkelsö C. Ventricular cerebrospinal fluid neurofilament protein levels decrease in parallel with white matter pathology after shunt surgery in normal pressure hydrocephalus. Eur J Neurol. 2007 Mar;14(3):248-54. PubMed PMID: 17355543.
2)

Hattori T, Ito K, Aoki S, Yuasa T, Sato R, Ishikawa M, et al: White matter alteration in idiopathic normal pressure hydrocephalus: tract-based spatial statistics study. AJNR Am J Neuroradiol 33:97–103, 2012
3)

Moseley ME, Cohen Y, Mintorovitch J, Chileuitt L, Shimizu H, Kucharczyk J, Wendland MF, Weinstein PR. Early detection of regional cerebral ischemia in cats: comparison of diffusion- and T2-weighted MRI and spectroscopy. Magn Reson Med. 1990 May;14(2):330-46. doi: 10.1002/mrm.1910140218. PMID: 2345513.

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