1p/19q co-deletion

1p/19q co-deletion


Currently, classification of neoplasms, especially regarding gliomas, is established on molecular mutations in isocitrate dehydrogenase (IDH) genes and the presence of 1p/19q co-deletion 2)


1p/19q co-deletion should be tested whenever oligodendroglial features are present or if oligodendroglioma is suspected on other grounds. This is tested using FISH (fluorescence in situ hybridization) or PCR. It is often sent out, results typically take 3–7 days. Cost for FISH is on the order of $200 U.S., PCR is $300–500 U.S


Oligodendrocyte transcriptional factor-2 (Olig2) is an essential marker for oligodendrocytes expression. Olig2 marker cannot be used as an alternative diagnostic method for 1p 19q co-deletion to distinguish oligodendrogliomas from other glial neoplasms. Although some glial tumors showed diffuse Olig2 expression, 1p19q co-deletion testing is the best diagnostic method 3).

1p/19q co-deletion has not been reported in central neurocytoma, but it can be seen in extraventricular neurocytoma.


2)

Casili G, Paterniti I, Campolo M, Esposito E, Cuzzocrea S. The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors. Adv Exp Med Biol. 2023;1394:41-49. doi: 10.1007/978-3-031-14732-6_3. PMID: 36587380.
3)

Kurdi M, Alkhatabi H, Butt N, Albayjani H, Aljhdali H, Mohamed F, Alsinani T, Baeesa S, Almuhaini E, Al-Ghafari A, Hakamy S, Faizo E, Bahakeem B. Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms? Folia Neuropathol. 2021;59(4):350-358. doi: 10.5114/fn.2021.112562. PMID: 35114775.