• The Role of Neuro-Inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors
• Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes
• A Patient With Epilepsy, Ganglioglioma, and Oligodendroglioma With Anaplastic Foci in the Same Left Frontoparietal Lesion: A Case Report
• Clinical Benefit of Bevacizumab and Irinotecan (BEV+IRI) in Patients With Relapsed/Refractory Glioblastoma (r/rGBM) and its Potential Predictors
• Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology
• Generation of chromosome 1p/19q co-deletion by CRISPR/Cas9-guided genomic editing
• Challenges in the Diagnosis and Management of Low-Grade Gliomas
• Identification and validation of roles of lysyl oxidases in the predictions of prognosis, chemotherapy and immunotherapy in glioma

1p19q codeletion stands for the combined loss of the short arm chromosome 1 (i.e. 1p) and the long arm of chromosome 19 (i.e. 19q) and is recognized as a genetic marker predictive of therapeutic response to both chemotherapy and combined chemoradiotherapy and overall longer survival in patients with diffuse gliomas, especially those with oligodendroglial components

IDH positive + 1p/19q co-deletion = oligodendroglioma = better prognosis

IDH positive + no 1p/19q co-deletion = astrocytoma ¹⁾

• Profiling of Carnitine Shuttle System Intermediates in Gliomas Using Solid-Phase Microextraction (SPME)
• Divining responder populations from survival data

Currently, classification of neoplasms, especially regarding gliomas, is established on molecular mutations in isocitrate dehydrogenase (IDH) genes and the presence of 1p/19q co-deletion ²⁾

1p/19q co-deletion should be tested whenever oligodendroglial features are present or if oligodendroglioma is suspected on other grounds. This is tested using FISH (fluorescence in situ hybridization) or PCR. It is often sent out, results typically take 3–7 days. Cost for FISH is on the order of $200 U.S., PCR is $300–500 U.S

Oligodendrocyte transcriptional factor-2 (Olig2) is an essential marker for oligodendrocytes expression. Olig2 marker cannot be used as an alternative diagnostic method for 1p 19q co-deletion to distinguish oligodendrogliomas from other glial neoplasms. Although some glial tumors showed diffuse Olig2 expression, 1p19q co-deletion testing is the best diagnostic method ³⁾.

Oligodendroglioma 1p/19q co-deletion.

Anaplastic astrocytoma without 1p/19q co-deletion.

1p/19q co-deletion has not been reported in central neurocytoma, but it can be seen in extraventricular neurocytoma.