Idiopathic normal pressure hydrocephalus Magnetic resonance imaging
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see Evans index
see Callosal angle
2. features that correlate with favorable response to shunt. These features suggest that the hydrocephalus is not due to atrophy alone. Note: atrophy / hydrocephalus ex vacuo, as in conditions such as Alzheimer’s disease, lessens the chance of, but does not preclude responding to a shunt (cortical atrophy is a common finding in healthy individuals of advanced age 1))
a) periventricular low density on CT or high intensity on T2WI MRI: may represent Transependymal edema. May resolve with shunting
b) compression of convexity sulci (as distinct from dilatation in atrophy). Note:focal sulcal dilation may sometimes be seen and may represent atypical reservoirs of CSF, which may diminish after shunting and should not be considered as atrophy 2).
c) rounding of the frontal horns
Other helpful findings in iNPH that require MRI
1. Japanese guidelines 3) for iNPH also identify the following features:
a) DESH hydrocephalus with enlarged subarachnoid spaces primarily in the Sylvian fissure and basal cisterns and effacement of the subarachnoid space over the convexity (so-called “tight high convexity”).
b) ventricular enlargement in iNPH deforms the corpus callosum,including:
● upward bowing and thinning (best appreciated on sagittal MRI)
2. phase-contrast MRI may demonstrate hyperdynamic flow of CSF through the aqueduct Although some patients improve with no change in ventricles, clinical improvement most often accompanies reduction of ventricular size.
In the sagittal volumetric T2 sequence, there is no clear occupation of the cerebral aqueduct, also observing the passage of cerebrospinal fluid through the aqueduct. He also appreciates flow artifact on T2 in the 3rd ventricle. The 3rd ventricle presents a slight increase in caliber with the 4th ventricle of normal size, however, the increase in the 3rd ventricle is much less than the lateral ventricular dilatation. Signs of chronic small vessel ischemic zone distributed in both cerebral hemispheres. A small area of encephalomalacia and right occipital gliosis due to sequelae of an old ischemic infarction.
NPH is characterized by an ongoing periventricular neuronal dysfunction seen on MRI as periventricular hyperintensity (PVH). Clinical improvement after shunt surgery is associated with CSF changes indicating a restitution of axonal function. Other biochemical effects of shunting may include increased monoaminergic and peptidergic neurotransmission, breakdown of blood brain barrier function, and gliosis 4).
An MRI-based diagnostic scheme used in a multicenter prospective study (Study of Idiopathic Normal Pressure Hydrocephalus on Neurological Improvement [SINPHONI]) appears to suggest that features of disproportionately enlarged subarachnoid-space hydrocephalus (DESH) are meaningful in the evaluation of NPH 5).
Phase contrast magnetic resonance imaging
Diffusion-weighted magnetic resonance imaging (DWI) 6) is used generally in the diagnosis and treatment of various neurodegenerative diseases. The apparent diffusion coefficient (ADC) of the brain, calculated from DWI data, is overestimated because of the effect of bulk motion (rigid body motion caused by the brain pulsation).