Articles published today

Cohen ZR, Ramishetti S, Peshes-Yaloz N, Goldsmith M, Wohl A, Zibly Z, Peer D. Localized RNAi Therapeutics of Chemoresistant Grade IV Glioma Using Hyaluronan-Grafted Lipid-Based Nanoparticles. ACS Nano. 2015 Jan 8. [Epub ahead
of print] PubMed PMID: 25558928.

Forster M, Heindl N, Hattingen E, Gessler F, Quick J, Seifert V, Senft C. Brain surface reformatted imaging (BSRI) for intraoperative neuronavigation in brain tumor surgery. Acta Neurochir (Wien). 2015 Jan 8. [Epub ahead of print] PubMed PMID: 25567079.
Bae JW, Kim YH, Kim S, Wang K, Shin H, Kang HJ, Park S, Phi JH. Langerhans cell histiocytosis causing acute optic neuropathy. Childs Nerv Syst. 2015 Jan 8.[Epub ahead of print] PubMed PMID: 25566821.
Aras AB, Guven M, Akman T, Alacam H, Kalkan Y, Silan C, Cosar M. Genistein Exerts Neuroprotective Effect on Focal Cerebral Ischemia Injury in Rats. Inflammation. 2015 Jan 8. [Epub ahead of print] PubMed PMID: 25567369.
Katznelson L. Bilateral adrenalectomy for Cushing’s disease. Pituitary. 2015 Jan 8. [Epub ahead of print] PubMed PMID: 25566751.
Han D, Zhang J, Wei W, Tao T, Hu Q, Wang Y, Wang X, Liu N, You Y. Fenofibrate induces G(0)/G (1) phase arrest by modulating the PPARα/FoxO1/p27(kip) pathway in human glioblastoma cells. Tumour Biol. 2015 Jan 8. [Epub ahead of print] PubMed
PMID: 25566967.

Predicting Recurrence after Chronic Subdural Haematoma Drainage

Recurrence of chronic subdural haematomas (CSDHs) after surgical drainage is a significant problem with rates up to 20%. This study focuses on determining factors predictive of haematoma recurrence and presents a scoring system stratifying recurrence risk for individual patients. Methods : Between the years 2005 and 2009, 331 consecutive patients with CSDHs treated with surgery were included in this study. Univariate and multivariate analyses were performed searching for risk factors of increased post-operative haematoma volume and haematoma recurrence requiring repeat drainage. Results: We found a 12% reoperation rate. CSDH septation (seen on computed tomogram scan) was found to be an independent risk factor for recurrence requiring reoperation (p=0.04). Larger post-operative subdural haematoma volume was also significantly associated with requiring a second drainage procedure (p<0.001). Independent risk factors of larger post-operative haematoma volume included septations within a CSDH (p<0.01), increased pre-operative haematoma volume (p<0.01), and a greater amount of parenchymal atrophy (p=0.04). A simple scoring system for quantifying recurrence risk was created and validated based on patient age (< or ≥80 years), haematoma volume (< or ≥160cc), and presence of septations within the subdural collection (yes or no). Conclusion: Septations within CSDHs are associated with larger post-operative residual haematoma collections requiring repeat drainage. When septations are clearly visible within a CSDH, craniotomy might be more suitable as a primary procedure as it allows greater access to a septated subdural collection. Our proposed scoring system combining haematoma volume, age, and presence of septations might be useful in identifying patients at higher risk for recurrence ((Jack A, O’Kelly C, McDougall C, Max Findlay J. Predicting Recurrence after Chronic Subdural Haematoma Drainage. Can J Neurol Sci. 2015 Jan 5:1-6. [Epub ahead of print] PubMed PMID: 25557536.))

Articles published today

1: Juvela S, Lehto H. Risk factors for all-cause death after diagnosis of
unruptured intracranial aneurysms. Neurology. 2015 Jan 7. pii:
10.1212/WNL.0000000000001207. [Epub ahead of print] PubMed PMID: 25568291.
2: Pera J, Ruigrok YM. More evidence against alcohol or smoking in patients with
unruptured intracranial aneurysm. Neurology. 2015 Jan 7. pii:
10.1212/WNL.0000000000001222. [Epub ahead of print] PubMed PMID: 25568290.
3: Majumdar M, Tan LA, Chen M. Critical assessment of the morbidity associated
with ruptured cerebral arteriovenous malformations. J Neurointerv Surg. 2015 Jan
7. pii: neurintsurg-2014-011517. doi: 10.1136/neurintsurg-2014-011517. [Epub
ahead of print] PubMed PMID: 25568227.
4: Neta M, Miezin FM, Nelson SM, Dubis JW, Dosenbach NU, Schlaggar BL, Petersen
SE. Spatial and temporal characteristics of error-related activity in the human
brain. J Neurosci. 2015 Jan 7;35(1):253-66. doi: 10.1523/JNEUROSCI.1313-14.2015.
PubMed PMID: 25568119.
5: Kato MA, Green N, O’Connell K, Till SD, Kramer DJ, Al-Khelaifi M, Han JH,
Pryor KO, Gobin Y, Proekt A. A retrospective analysis of severe intraoperative
respiratory compliance changes during ophthalmic arterial chemosurgery for
retinoblastoma. Paediatr Anaesth. 2015 Jan 7. doi: 10.1111/pan.12603. [Epub ahead
of print] PubMed PMID: 25565164.
6: Sjölund J, Forsberg D, Andersson M, Knutsson H. Generating patient specific
pseudo-CT of the head from MR using atlas-based regression. Phys Med Biol. 2015
Jan 7;60(2):825-839. [Epub ahead of print] PubMed PMID: 25565133.
7: Li H, He X, Li X, Zhang X, Liu Y, Duan C. Treatment of giant/large internal
carotid aneurysms: parent artery occlusion or stent-assisted coiling. Int J
Neurosci. 2015 Jan 7. [Epub ahead of print] PubMed PMID: 25565057.
8: Liu H, Liu Z, Jiang B, Huo L, Liu J, Lu J. Synthetic miR-145 Mimic Enhances
the Cytotoxic Effect of the Antiangiogenic Drug Sunitinib in Glioblastoma. Cell
Biochem Biophys. 2015 Jan 7. [Epub ahead of print] PubMed PMID: 25564360.
9: Diksic M, Swoboda V. In memoriam: William Feindel, O.C., G.O.Q., MDCM, D.
Phil; July 12, 1918-January 12, 2014. J Cereb Blood Flow Metab. 2015 Jan 7. doi:
10.1038/jcbfm.2014.234. [Epub ahead of print] PubMed PMID: 25564242.
10: Xu H, Xu B, Wang Z, Tan G, Shen S. Inhibition of Wnt/β-catenin signal is
alleviated reactive gliosis in rats with hydrocephalus. Childs Nerv Syst. 2015
Jan 7. [Epub ahead of print] PubMed PMID: 25564198.
11: Beez T, Sarikaya-Seiwert S, Steiger H, Hänggi D. Real-time ultrasound
guidance for ventricular catheter placement in pediatric cerebrospinal fluid
shunts. Childs Nerv Syst. 2015 Jan 7. [Epub ahead of print] PubMed PMID:
25564197.
12: Wang C, Ji H, Chen S, Zhang G, Jia G. Clinical significance of lesser
occipital nerve preservation during micro-vascular decompression for hemi-facial
spasm. Ir J Med Sci. 2015 Jan 7. [Epub ahead of print] PubMed PMID: 25564009.
13: Takeshima Y, Tanaka Y, Hironaka Y, Shida Y, Nakase H. Visualization of
vascular structure of spinal hemangioblastoma using intraoperative indocyanine
green videoangiography and temporary feeder occlusion. Eur Spine J. 2015 Jan 7.
[Epub ahead of print] PubMed PMID: 25563200.
14: Brandman DM, Haji FA, Matte MC, Clarke DB. Needs Assessment for Incoming
PGY-1 Residents in Neurosurgical Residency. Can J Neurol Sci. 2015 Jan 7:1-8.
[Epub ahead of print] PubMed PMID: 25563071.
15: Tremblay S, Pieper F, Sachs A, Martinez-Trujillo J. Attentional Filtering of
Visual Information by Neuronal Ensembles in the Primate Lateral Prefrontal
Cortex. Neuron. 2015 Jan 7;85(1):202-215. doi: 10.1016/j.neuron.2014.11.021. Epub
2014 Dec 11. PubMed PMID: 25500502.
16: Cui T. MTHFR C677T mutation increased the risk of Ischemic Stroke, especially
in large-artery atherosclerosis in adults: an updated meta-analysis from 38
researches. Int J Neurosci. 2015 Jan 7. [Epub ahead of print] PubMed PMID:
25453894.
17: Del Brutto OH, Salgado P, Lama J, Del Brutto VJ, Campos X, Zambrano M, García
HH. Calcified neurocysticercosis associates with hippocampal atrophy: a
population-based study. Am J Trop Med Hyg. 2015 Jan 7;92(1):64-8. doi:
10.4269/ajtmh.14-0453. Epub 2014 Oct 27. PubMed PMID: 25349375.

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