Mesial temporal lobe lesion approaches

Mesial temporal lobe lesion approaches

There are several ways to safely access mesial temporal structures. The transsylvian-transcisternal approach is a good way to access the mesial structures while preserving the lateral and basal temporal structures. Actual lesions associated with epileptogenesis in focal cortical dysplasia (FCD) may be larger than they appear on magnetic resonance imaging. For this reason, evaluations to locate sufficient epileptogenic foci, including invasive studies, should be completed for FCD, and epilepsy surgery should be performed according to these results. Regardless, the ultimate goal of all epilepsy surgeries is to maximize seizure control while maintaining neurological function. Therefore, a tailored approach based on the properties of the lesion is needed1).

For Campero et al., dividing the mesial temporal region (MTR) into 3 regions allows us to adapt the approach to lesion location. Thus, the anterior sector can be approached via the sylvian fissure, the middle sector can be approached transtemporally, and the posterior sector can be approached via the supracerebellar approach 2).

There are limited reports on the transcortical approach for the resection of tumors within this region.

Morshed et al., from the UCSF Medical Center, described the technical considerations and functional outcomes in patients undergoing transcortical resection of gliomas of the mesial temporal lobe (MTL).

Patients with a glioma (WHO grades I-IV) located within the MTL who had undergone the transcortical approach in the period between 1998 and 2016 were identified through the University of California, San Francisco (UCSF) tumor registry and were classified according to tumor location: preuncus, uncus, hippocampus/parahippocampus, and various combinations of the former groups. Patient and tumor characteristics and outcomes were determined from operative, radiology, pathology, and other clinical reports that were available through the UCSF electronic medical record.

Fifty patients with low- or high grade glioma were identified. The mean patient age was 46.8 years, and the mean follow-up was 3 years. Seizures were the presenting symptom in 82% of cases. Schramm classification types A, C, and D represented 34%, 28%, and 38% of the tumors, and the majority of lesions were located at least in part within the hippocampus/parahippocampus. For preuncus and preuncus/uncus tumors, a transcortical approach through the temporal pole allowed for resection. For most tumors of the uncus and those extending into the hippocampus/parahippocampus, a corticectomy was performed within the middle and/or inferior temporal gyri to approach the lesion. To locate the safest corridor for the corticectomy, language mapping was performed in 96.9% of the left-sided tumor cases, and subcortical motor mapping was performed in 52% of all cases. The mean volumetric extent of resection of low- and high-grade tumors was 89.5% and 96.0%, respectively, and did not differ by tumor location or Schramm type. By 3 months’ follow-up, 12 patients (24%) had residual deficits, most of which were visual field deficits. Three patients with left-sided tumors (9.4% of dominant-cortex lesions) experienced word-finding difficulty at 3 months after resection, but 2 of these patients demonstrated complete resolution of symptoms by 1 year.

Mesial temporal lobe gliomas, including larger Schramm type C and D tumors, can be safely and aggressively resected via a transcortical equatorial approach when used in conjunction with cortical and subcortical mapping 3).


Microsurgery was performed via transsylviantranstemporal, or subtemporal approaches on 62 patients with mesial temporal lobe gliomas, 33 with localized tumors within the mesial temporal structures (type A), 19 in anterior portion (type A1), and 14 extending to posterior portion (type A2); 19 patients with multicompartmental tumors involving the mesial temporal lobe, insular lobe, and posterior frontorbital gurus (type B); 14 patients with tumors involving the temporal pole and lateral areas of the temporal horn (type C); and 6 patients with tumors infiltrating the brain stem, basal nuclei and thalamus (type D).

Trans-sylvian approach was performed in 25 cases of which total tumor removal was achieved in 14 cases, subtotal removal in 6 cases, and gross removal in 5 cases. Primary visual deficits worsened after surgery in 5 cases. Trans-temporal approach was used in 23 cases of which total tumor resection was achieved in 15 cases, subtotal resection in 5 cases, and gross resection in 3 cases. Primary visual deficits worsened after surgery in 5 cases. Four patients in which preoperative vision were good presented with visual deficits postoperatively. Subtemporal approach was used in 14 cases of which total tumor removal was achieved in 10 cases, and subtotal removal in 4 cases. All 14 patients did not develop worsened vision after surgery.

Trans-sylvian and subtemporal approaches can reduce possible harm to parenchyma and optic radiation, whereas approaches to the temporal horn through the superior and middle temporal gyri will induce damage to parenchyma and optic radiation 4).


The aim of Faust et al., was to categorize temporal lobe tumors based on anatomical, functional, and vascular considerations and to devise a systematic field manual of surgical approaches.

Tumors were classified into four main types with assigned approaches: Type I-lateral: transcortical; type II-polar: pterional/transcortical; type III-central: transsylvian/transopercular; type IV-mesial: transsylvian/trans-cisternal if more anterior (=Type IV A), and supratentorial/infraoccipital if more posterior (=type IV B). 105 patients have been operated on prospectively using the advocated guidelines. Outcomes were evaluated.

Systematic application of the proposed classification facilitated a tailored approach, with gross total tumor resection of 88 %. Neurological and surgical morbidity were less than 10 %. The proposed classification may prove a valuable tool for surgical planning 5).


Twenty formalin-fixed, adult cadaveric specimens were studied. Ten brains provided measurements to compare different surgical strategies. Approaches were demonstrated using 10 silicon-injected cadaveric heads. Surgical cases were used to illustrate the results by the different approaches. Transverse lines at the level of the inferior choroidal point and quadrigeminal plate were used to divide the medial temporal region into anterior, middle, and posterior portions. Surgical approaches to the medial temporal region were classified into four groups: superior, lateral, basal, and medial, based on the surface of the lobe through which the approach was directed. The approaches through the medial group were subdivided further into an anterior approach, the transsylvian transcisternal approach, and two posterior approaches, the occipital interhemispheric and supracerebellar transtentorial approaches.

The anterior portion of the medial temporal region can be reached through the superior, lateral, and basal surfaces of the lobe and the anterior variant of the approach through the medial surface. The posterior group of approaches directed through the medial surface are useful for lesions located in the posterior portion. The middle part of the medial temporal region is the most challenging area to expose, where the approach must be tailored according to the nature of the lesion and its extension to other medial temporal areas.

Each approach to medial temporal lesions has technical or functional drawbacks that should be considered when selecting a surgical treatment for a given patient. Dividing the medial temporal region into smaller areas allows for a more precise analysis, not only of the expected anatomic relationships, but also of the possible choices for the safe resection of the lesion. The systematization used here also provides the basis for selection of a combination of approaches 6).


Germano described a transsulcal temporal approach to mesiotemporal lesions and its application in three patients. Gross-total resection of the lesion was accomplished in all cases. An anatomical cadaveric study was also performed to delineate the microsurgical anatomy of this approach. Precise knowledge of temporal intraventricular landmarks allows navigation to the lesion without the need for a navigational system. This approach is helpful for neurologically intact patients with mesiotemporal lesions 7).

References

1)

Chong S, Phi JH, Lee JY, Kim SK. Surgical Treatment of Lesional Mesial Temporal Lobe Epilepsy. J Epilepsy Res. 2018 Jun 30;8(1):6-11. doi: 10.14581/jer.18002. eCollection 2018 Jun. Review. PubMed PMID: 30090756; PubMed Central PMCID: PMC6066696.
2)

Campero A, Ajler P, Rica C, Rhoton A Jr. Cavernomas and Arteriovenous Malformations in the Mesial Temporal Region: Microsurgical Anatomy and Approaches. Oper Neurosurg (Hagerstown). 2017 Feb 1;13(1):113-123. doi: 10.1227/NEU.0000000000001239. PubMed PMID: 28931254.
3)

Morshed RA, Young JS, Han SJ, Hervey-Jumper SL, Berger MS. The transcortical equatorial approach for gliomas of the mesial temporal lobe: techniques and functional outcomes. J Neurosurg. 2018 Apr 20:1-9. doi: 10.3171/2017.10.JNS172055. [Epub ahead of print] PubMed PMID: 29676697.
4)

Jiang ZL, Wang ZC, Jiang T. [Surgical outcomes of different approaches for mesial temporal lobe gliomas]. Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2428-32. Chinese. PubMed PMID: 16321253.
5)

Faust K, Schmiedek P, Vajkoczy P. Approaches to temporal lobe lesions: a proposal for classification. Acta Neurochir (Wien). 2014 Feb;156(2):409-13. doi: 10.1007/s00701-013-1917-4. Epub 2013 Nov 8. Review. PubMed PMID: 24201756.
6)

Campero A, Tróccoli G, Martins C, Fernandez-Miranda JC, Yasuda A, Rhoton AL Jr. Microsurgical approaches to the medial temporal region: an anatomical study. Neurosurgery. 2006 Oct;59(4 Suppl 2):ONS279-307; discussion ONS307-8. PubMed PMID: 17041498.
7)

Germano IM. Transsulcal approach to mesiotemporal lesions. Anatomy, technique, and report of three cases. Neurosurg Focus. 1996 Nov 15;1(5):e4. PubMed PMID: 15099055.

Spinal cord subependymoma

Spinal cord subependymoma

spinal cord subependymoma (SCSE) is a benign, non-invasive, slow-growing, WHO Grade I spinal cord tumor 1), first reported by Boykin et al. in 19542).

Epidemiology

Their most common site of occurrence is the fourth ventriclefollowed by the lateral ventricles. Spinal cord subependymomas typically manifest as cervical and cervicothoracic intramedullary or, rarely, extramedullary mass lesions.

Pathology

Histologically, there are hypocellular areas with occasional clusters of cells and frequent microcystic changes, calcifications, and hemorrhage. Radiologically, subependymomas generally manifest as eccentric well circumscribed nodular lesions with mild-to-moderate enhancement.

Clinical features

They often present clinically with pain and neurologic symptoms, including motor, sensory, urinary, and sexual dysfunction.

Diagnosis

Toi et al., made an important discovery of what seems to be a characteristic appearance for spinal subependymoma on sagittal MRI. Swelling of the spinal cord is extremely steep, providing unusually large fusiform dilatation resembling a bamboo leaf. They termed this characteristic MRI appearance as the “bamboo leaf sign.” This characteristic was apparent in 76.2% of cases of spinal subependymoma for which MRI findings were reported. Conclusion. The bamboo leaf sign on spinal MRI is useful for differentiating between subependymoma and other intramedullary tumors. Neurosurgeons encountering the bamboo leaf sign on spinal MRI should consider the possibility of subependymoma 3).

Differential diagnosis

It is not easily differentiable from a spinal cord ependymoma with radiological findings.

Treatment

Spinal cord subependymomas are not dissected easily from the spinal cord. Considering the rather indolent nature of spinal cord subependymomas, subtotal removal without the risk of neurological deficit is another option 4).

Outcome

Surgical findings and outcomes differ from those of an ependymoma, including a high risk of neurological deficit in the event of a poor dissection plane from the spinal cord with a low rate of recurrence.

Case series

Mikula et al., present a series of spinal cord subependymomas with a detailed description of the clinical, radiological and pathological features, and characterization by chromosomal microarray analysis. Briefly, the four patients included two men and two women, between the ages of 22 and 48 years. The most common presenting symptoms were neck and arm pain with upper extremity weakness. By imaging, the tumors were found to involve multiple spinal levels, including cervical/ cervico-thoracic (three patients) and thoracic (one patient), were all eccentric, and had minimal to no post-contrast enhancement. Two patients underwent gross total resection, one had a sub-total resection, and one underwent biopsy alone with a decompressive laminectomy. Follow up ranged from 6 months to 22 years. One patient (case 4) had recurrence 15 years following gross total resection and chromosomal microarray analysis revealed deletions on the long arm of chromosome 6. Our limited series suggests that spinal cord subependymomas can rarely recur, even following gross total resection, suggesting a possible role for long-term surveillance for these rare tumors5).


Yuh et al., retrospectively reviewed the medical records of ten spinal cord subependymoma patients (M : F=4 : 6; median 38 years; range, 21-77) from four institutions.

The most common symptoms were sensory changes and/or pain in eight patients, followed by motor weakness in six. The median duration of symptoms was 9.5 months. Preoperative radiological diagnosis was ependymoma in seven and astrocytoma in three. The tumors were located eccentrically in six and were not enhanced in six. Gross total resection of the tumor was achieved in five patients, whereas subtotal or partial resection was inevitable in the other five patients due to a poor dissection plane. Adjuvant radiotherapy was performed in two patients. Neurological deterioration occurred in two patients; transient weakness in one after subtotal resection and permanent weakness after gross total resection in the other. Recurrence or regrowth of the tumor was not observed during the median 31.5 months follow-up period (range, 8-89).

Spinal cord subependymoma should be considered when the tumor is located eccentrically and is not dissected easily from the spinal cord. Considering the rather indolent nature of spinal cord subependymomas, subtotal removal without the risk of neurological deficit is another option 6).

Case reports

A 51-year-old man presented with a 2-year history of progressive muscle weakness in the right lower extremity. Sagittal magnetic resonance imaging (MRI) showed spinal cord expansion at the Th7-12 vertebral level. Surgical resection was performed and the tumor was found to involve predominantly subpial growth. Histological diagnosis was subependymoma, classified as Grade I according to criteria of World Health Organization. They made an important discovery of what seems to be a characteristic appearance for spinal subependymoma on sagittal MRI. Swelling of the spinal cord is extremely steep, providing unusually large fusiform dilatation resembling a bamboo leaf. They termed this characteristic MRI appearance as the “bamboo leaf sign.” This characteristic was apparent in 76.2% of cases of spinal subependymoma for which MRI findings were reported. Conclusion. The bamboo leaf sign on spinal MRI is useful for differentiating between subependymoma and other intramedullary tumors. Neurosurgeons encountering the bamboo leaf sign on spinal MRI should consider the possibility of subependymoma 7).


A case report of a single patient in whom a subependymoma was resected from the cervical spinal cord with return to normal functioning.

Clinical examination, magnetic resonance imaging evaluation, surgical resection, and histological analysis were performed for diagnosis and treatment of this patient.

The patient experiencing myelopathy symptoms underwent a surgical resection of cervical spinal cord subependymoma that resulted in return to normal function.

Subependymoma should be included in the differential diagnosis of atypical presentations for myelopathy, as discrete surgical resection can result in good outcome 8).


A 53 year old man with a progressive paraparesis, paraesthesias of the lower limbs and sphincter disturbance. The tumour was partly removed, without progression 5 years after surgery 9).

References

1)

Im SH, Paek SH, Choi YL, Chi JG, Kim DG, Jung HW, Cho BK. Clinicopathological study of seven cases of symptomatic supratentorial subependymoma. J Neurooncol. 2003 Jan;61(1):57-67. PubMed PMID: 12587796.
2)

BOYKIN FC, COWEN D, IANNUCCI CA, WOLF A. Subependymal glomerate astrocytomas. J Neuropathol Exp Neurol. 1954 Jan;13(1):30-49. PubMed PMID: 13118373.
3) , 7)

Toi H, Ogawa Y, Kinoshita K, Hirai S, Takai H, Hara K, Matsushita N, Matsubara S, Uno M. Bamboo Leaf Sign as a Sensitive Magnetic Resonance Imaging Finding in Spinal Subependymoma: Case Report and Literature Review. Case Rep Neurol Med. 2016;2016:9108641. doi: 10.1155/2016/9108641. Epub 2016 Dec 15. PubMed PMID: 28074165; PubMed Central PMCID: PMC5198089.
4) , 6)

Yuh WT, Chung CK, Park SH, Kim KJ, Lee SH, Kim KT. Spinal Cord Subependymoma Surgery : A Multi-Institutional Experience. J Korean Neurosurg Soc. 2018 Mar;61(2):233-242. doi: 10.3340/jkns.2017.0405.001. Epub 2018 Feb 28. PubMed PMID: 29526067; PubMed Central PMCID: PMC5853201.
5)

Mikula AL, Paolini MA, Sukov WR, Clarke MJ, Raghunathan A. Subependymoma involving multiple spinal cord levels: A clinicopathological case series with chromosomal microarray analysis. Neuropathology. 2019 Mar 11. doi: 10.1111/neup.12543. [Epub ahead of print] PubMed PMID: 30856298.
8)

Cure LM, Hancock CR, Barrocas AM, Sternau LL, C Hirzel A. Interesting case of subependymoma of the spinal cord. Spine J. 2014 May 1;14(5):e9-12. doi: 10.1016/j.spinee.2013.10.056. Epub 2013 Nov 20. PubMed PMID: 24269267.
9)

Dario A, Fachinetti P, Cerati M, Dorizzi A. Subependymoma of the spinal cord: case report and review of the literature. J Clin Neurosci. 2001 Jan;8(1):48-50. PubMed PMID: 11148079.

White Matter Surgery-Third annual Hands-on Course London

A UNIQUE, ANNUAL, HANDS-ON COURSE ON CORTICAL AND WHITE MATTER ANATOMY, MAPPING AND SURGERY

A series of cadaveric brain dissections prepared with the Klinger technique, along with Masters’ Seminars on white matter tracts function, connectivity and cortical parcellation, and intra-operative mapping, and step-by-step surgical techniques on challenging surgical approaches.

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