clinical

New Book:Traumatic Brain Injury, Part I, Volume 127: Handbook of Clinical Neurology

Traumatic Brain Injury, Part I, Volume 127: Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)Traumatic Brain Injury, Part I, Volume 127: Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

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The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.

  • Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury
  • Explores cellular and molecular mechanisms as well as genetic predictors of outcome
  • Offers coverage of various diagnostic tools – CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more
  • State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care

Product Details

  • Binding: Hardcover
  • 490 pages

Editorial Reviews

About the Author
Jordan Grafman, PhD, is director of Brain Injury Research at the Rehabilitation Institute of Chicago. Before joining RIC, Dr. Grafman was director of the Traumatic Brain Injury Research at Kessler Foundation. His investigation of brain function and behavior contributes to advances in medicine, rehabilitation, and psychology, and informs ethics, law, philosophy, and health policy. His study of the human prefrontal cortex and cognitive neuroplasticity incorporates neuroimaging and genetics, an approach that is expanding our knowledge of the impact of traumatic brain injury, as well as other diseases that impair brain function, such as stroke, multiple sclerosis and degenerative diseases. Dr. Grafman aims to translate his research into more effective, targeted rehabilitation to achieve the best outcomes for people with cognitive disabilities. Dr. Grafman’s background includes 30 years of experience in brain injury research. He has studied brain function in dementia, depression, and degenerative neurological diseases, as well as TBI. He has authored more than 300 research publications, co-editor of the journal Cortex, and provides peer review for numerous specialty journals. At the National Institutes of Health, he served as chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke. While in the US Air Force, he served at Walter Reed Army Medical Center as neuropsychology chief of the Vietnam Head Injury Project, a long-term study of more than 500 soldiers with serious injuries of the head and brain. He is the leading expert on the long-term effects of penetrating brain injuries in military personnel. His expertise includes the scope of challenges faced during recovery, including behavioral changes like aggression, late sequelae such as seizures, and the impact on TBI on family life and employment, and legal implications. He is an elected fellow of the American Psychological Association and the New York Academy of Sciences. Dr. Grafman is the recipient of many prestigious awards including the Department of Defense Meritorious Service Award, the National Institutes of Health Award of Merit, 2010 National Institutes of Health Director’s Award, and the Humboldt Reserach Award. He is a frequent speaker at national and international conferences. His expert opinion is often sought by national media on issues related to brain function and behavior, cognitive rehabilitation, and policy and legal issues related to brain-behavior research.

New Book: Neurosurgery: The Essential Guide to the Oral and Clinical Neurosurgical Exam

Neurosurgery: The Essential Guide to the Oral and Clinical Neurosurgical Exam

By Vivian A. Elwell, Ramez Kirollos, Syed Al-Haddad

Neurosurgery: The Essential Guide to the Oral and Clinical Neurosurgical Exam

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 Product Description

Neurosurgery: The Essential Guide to the Oral and Clinical Neurosurgical Examination is the first book of its kind to cover the International and Intercollegiate FRCS Specialty Examination in Neurosurgery. It will also help you prepare for the American Board of Neurological Surgery (ABNS) examination and other neurosurgical examinations around the world. Written by neurosurgeons, this book is a hands-on guide that translates basic science and theories of neurosurgery into clinical practice. This comprehensive resource takes a standardized and logical approach to the clinical neurosurgical examination. Based on the authors’ own clinical practice, teaching and examination experiences, this book provides candidates with a firm grasp of neuroscience and the ability to solve problems under pressure.
Scenario- and patient-based, the book covers history-taking, clinical examination, differential diagnosis, investigations, management, treatment options and potential complications. The text is based on the Royal College of Surgeons of England and U.S. board syllabuses. In addition to serving as a reliable preparation resource for the neurosurgical examination, it will also be invaluable in your future surgical practice.

Product Details

  • Amazon Sales Rank: #485213 in Books
  • Published on: 2014-12-16
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.69″ h x .35″ w x 7.44″ l,
  • Binding: Paperback
  • 181 pages

Editorial Reviews

About the Author
Miss Vivian A. Elwell is currently working as a Post-CCT Senior Spinal Fellow at The National Hospital for Neurology and Neurosurgery in London. Miss Elwell’s awards include the Swinford Edward Silver Medal Prize for her OSCE Examination; the Columbia University Research Fellowship at Columbia College of Physicians and Surgeons in New York City, USA; the Columbia University King’s Crown Gold and Silver Medal Awards; the Kathrine Dulin Folger Cancer Research Fellowship and the ‘Who’s Who Young Scientists Award’. In 2010, she was a finalist for the BMA’s Junior Doctor of the Year Award. Miss Elwell received her BA from Columbia College, Columbia University, and her MA from the University of Cambridge. She earned a Bachelor of Medicine and Bachelor of Surgery from the Imperial College School of Medicine. She is a Fellow of the Royal College of Surgeons.
Mr Ramez Kirollos is a Consultant Neurosurgeon at Addenbrooke’s Hospital in Cambridge. His main clinical interests include anterior and middle skull base, pituitary and pineal surgery, and surgical treatment of arteriovenous malformations. A passion for neurosurgical technique based on the thorough understanding of anatomy has accompanied Mr Kirollos’ neurosurgical training and forms the basis of his surgical practice. Dr Kirollos oversees weekly registrar teaching sessions at Addenbrooke’s Hospital, and serves on the faculty for Neuroanatomy of Operative Approaches and the British Neurosurgical Trainee. In 2006, Dr Kirollos was elected as a member of the Court of Examiners of the Royal College of Surgeons of England. In 2010, for his commitment to surgical education, he received the prestigious Silver Scalpel Award. He is the chairman of the British Neurovascular Group (2013-2015).
Mr Syed Al-Haddad is a Consultant Neurosurgeon at Aberdeen Royal Infirmary, Scotland. He commenced his neurosurgical training at the Walton Centre in Liverpool, where he developed his interest in neuro-oncology research. He undertook further training in neurosurgery in Manchester, Leeds, Aberdeen and Edinburgh. He has been actively involved in teaching both undergraduate and postgraduate students and is a faculty member for Leeds and Edinburgh operative neuroanatomy courses. He has published numerous articles in peer-reviewed journals. Mr Al-Haddad is the founder and director of the highly successful Aberdeen FRCS (SN) Viva course, which gives practical advice to neurosurgeons preparing for the challenge of the neurosurgical exam.

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New Book: Deep Brain Stimulation for Neurological Disorders: Theoretical Background and Clinical Application

Deep Brain Stimulation for Neurological Disorders: Theoretical Background and Clinical Application

Deep Brain Stimulation for Neurological Disorders: Theoretical Background and Clinical Application
List Price: $179.00
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Chronic electrical stimulation of the brain has demonstrated excellent outcomes in patients with Parkinson’s disease and has recently also been applied to various other neurological diseases. This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts in the field from across the world.

Product Details

  • Original language: English
  • Number of items: 1
  • Dimensions: 10.20″ h x .59″ w x 7.28″ l,
  • Binding: Hardcover
  • 208 pages

Editorial Reviews

From the Back Cover
Chronic electrical stimulation of the brain has become a standard surgical therapy for Parkinson’s disease, with many studies demonstrating excellent outcomes without any serious complications. Recently this surgical intervention has also been applied to various other neurological diseases, such as involuntary movement disorders, intractable pain, and psychological conditions including depression and obsessive-compulsive disorder.
This comprehensive, up-to-date textbook will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus, and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique.
The authors are outstanding scientists and experts in the field from across the world. This book will be welcomed by all young neurosurgeons, neurologists, psychiatrists, and other medical staff who are interested in electrical stimulation of the brain for the treatment of neurological disorders.
About the Author
Toru Itakura, MD, PhD, graduated from Wakayama Medical University, Japan, in 1970 and subsequently gained a PhD in Neurological Surgery from the same university. He became an Assistant Professor in the Department of Neurological Surgery, Wakayama Medical University in 1983, an Associate Professor in 1992 and full Professor in 1994. In 2008 Professor Itakura became Chairman of Wakayama Medical University School of Medicine and since 2010 he has been President of Wakayama Medical University.

New Book:Clinical Neuroendocrinology, Volume 124 (Handbook of Clinical Neurology)

Clinical Neuroendocrinology, Volume 124 (Handbook of Clinical Neurology)

Clinical Neuroendocrinology, Volume 124 (Handbook of Clinical Neurology)

List Price:$275.00
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Clinical Neuroendocrinology, a volume in the Handbook of Clinical Neurology Series gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.
*All contributors are recognized experts in the different fields of clinical neuroendocrinology *The book provides expanded coverage on hypothalamic mechanisms in human pathophysiology *The book includes current perspectives, diagnosis and treatment of pituitary diseases

Product Details

  • Original language: English
  • Number of items: 1
  • Dimensions: 10.59″ h x 1.06″ w x 7.83″ l, 3.22 pounds
  • Binding: Hardcover
  • 456 pages

Editorial Reviews

From the Back Cover
The book gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.
About the Author
Eric Fliers is Professor of Endocrinology at the University of Amsterdam, serving as head of the Department of Endocrinology and Metabolism at the Academic Medical Center in Amsterdam since 2007. He received a PhD in Neuroscience on the functional neuroanatomy of the human hypothalamus, followed by his MD (with honors), both from the University of Amsterdam. He was subsequently trained as an internist-endocrinologist. Fliers was one of the founders of the Netherlands Brain Bank. His current research interests include the hypothalamus-pituitary-thyroid axis, and the neuro-endocrine response to illness. Eric Fliers is the current chair of the Dutch Endocrine Society.
Prof. Márta Korbonits is a clinical academic endocrinologist with special interest in pituitary tumorigenesis and as well as metabolic effects of hormones. She graduated in medicine at Semmelweis Medical School in Budapest and works in the Department of Endocrinology at Barts and the London School of Medicine at St. Bartholomew’s Hospital in London since 1991, where currently she is Co-Centre Head. She received an MD and a PhD from the University of London and was a recipient of a Medical Research Council Clinician Scientist Fellowship to study ghrelin physiology and genetics. Her current interests include hormonal regulation of the metabolic enzyme AMP-activated protein kinase, the physiology and pathophysiology of ghrelin and endocannabinoids and pituitary tumours including familial cases. She has a large collection of familial isolated pituitary adenoma families and works on both the clinical characterization as well as molecular aspects of this disease.
She has published over 160 papers, numerous book chapters, and edited two books in the field of Endocrinology and has been an invited speaker on medical conferences all over the world. She serves on the editorial board of several prestigious endocrine journals and serves as referee for numerous high-impact journals and grant-giving bodies. She was heading the Program Organizing Committee of the Society for Endocrinology for three years, served on the Executive Committee of the Pituitary Society and ENEA and currently the European Society of Clinical Investigation and is an elected member of the Association of Physicians of Great Britain and Ireland. She has received numerous awards including the Nicholas Zervas Lectureship at Massachusetts General Hospital, Harvard Medical School and the prestigious Society for Endocrinology Medal.
She shares her time between clinical patient care, clinical research and laboratory based research as well as teaching at undergraduate and postgraduate level.
Johannes A. (Hans) Romijn was trained in internal medicine in the Academic Medical Center, University of Amsterdam, followed by fellowships in intensive care and clinical endocrinology. He was professor and chairman of Medicine and of Endocrinology at the Leiden University Medical Center, The Netherlands between 1998 and 2010. Since 2010 he serves as professor and chairman of the Division and Department of Medicine, Academic Medical Center, University of Amsterdam in The Netherlands. He is currently the Editor-in-Chief of the European Journal of Endocrinology, the leading journal of the European Society of Endocrinology. His research focuses on the pathophysiology of endocrine and metabolic regulation, with a special focus on clinical neuroendocrinolog

New Book: Endovascular Surgical Neuroradiology: Theory and Clinical Practice

Endovascular Surgical Neuroradiology: Theory and Clinical Practice

Endovascular Surgical Neuroradiology: Theory and Clinical Practice

List Price:$279.99
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It covers all aspects of neuroendovascular surgery, such as the science of vascular biology to the more advanced clinical applications in acute stroke interventions and Arteriovenous malformations. Written by neurologists, neurosurgeons, and neuroradiologists, this timely text provides readers with a thorough review of all the considerations pertinent to the endovascular treatment of diseases of the cerebrovascular system, spine, head, and neck.
Key Features:

  • Technique chapters include complication avoidance and management
  • High-quality, unique illustrations and up-to-date images guide the reader through clinical concepts and technically challenging procedures
  • Covers topics that are often overlooked but are critical to understanding the dynamics of endovascular treatment, such as the use of anticoagulants or procoagulants and the biophysics of vascular disease
  • Each chapter ends with a Summary which distills and highlights the key takeaways for that topic

Product Details

  • Published on: 2014-10-15
  • Original language: English
  • Binding: Hardcover
  • 590 pages

Intracranial hypotension: clinical presentation, imaging findings, and imaging-guided therapy

Intracranial hypotension is a condition in which there is negative pressure within the brain cavity.

Etiology

see Spontaneous intracranial hypotension
Cerebrospinal fluid leak from the spinal canal:
A leak following a lumbar puncture (spinal tap).
A defect in the dura
Sometimes following exertion such as swinging a golf club.
A congenital weakness.
Following spinal surgery.
Following spinal trauma.
Following a shunt procedure for hydrocephalus.
Lumboperitoneal shunt.
Ventriculoperitoneal shunt with a low pressure valve.
In some cases, spinal CSF leaks can lead to a descent of the cerebellar tonsils into the spinal canal, similar to a Chiari malformation.
Large spinal dural defects can lead to herniation of the spinal cord into the defect.

Symptoms

The classic symptom is severe headache when upright, which is relieved when lying flat.
Other symptoms can include nausea, vomiting, double vision and difficulty with concentration.
The typical clinical manifestation – orthostatic headache – may be masqueraded by atypical clinical findings, including coma, frontotemporal dementia, leptomeningeal hemosiderosis-associated symptoms, and others.

Diagnosis

Diagnosis is usually suspected based on the postural dependency of the headache, although in many cases the diagnosis of intracranial hypotension is not considered for some time.
A contrast-enhanced brain magnetic response imaging (MRI) scan typically shows thickened and brightly enhancing meninges (pachymeningeal enhancement). Other findings include descent of the thalamus and cerebellar tonsils.
MRI signs are highly specific, but the imaging strategy to search for spinal cerebrospinal fluid leaks (none, computed tomography myelography, magnetic resonance myelography with gadolinium, digital subtraction myelography) is a matter of debate 1).
Continuous intracranial pressure monitoring is definitive for documenting abnormally negative intracranial pressures.
The identification of the site of CSF leak in the spinal canal can be very challenging. In some cases, the site cannot be identified. Methods include:
Dynamic myelography with fluoroscopy and computed tomography (CT).
Radioisotope cisternography.
Spinal MRI.

Treatment

If the site of the spinal CSF leak can be identified, then options include:
Epidural blood patch, performed by an anesthesiologist pain management specialist.
Surgical repair of the defect.
Over-draining CSF shunts are managed by replacing the valve with one that drains less.
Lumboperitoneal shunts may have to be removed or ligated.

Outcome

If the cause of the intracranial hypotension can be identified, the outcome following treatment is typically excellent.
1) Urbach H. Intracranial hypotension: clinical presentation, imaging findings, and imaging-guided therapy. Curr Opin Neurol. 2014 Aug;27(4):414-24. doi: 10.1097/WCO.0000000000000105. PubMed PMID: 24978633.

Clinical Fellowship – Head and Neck Oncology/Skull Base Surgery

Aurora-St. Lukes’s Hospital Fellowship in Head and Neck Oncologic Surgery and Skull Base Surgery is a one year fellowship intended for Otolaryngologists-Head and Neck Surgeons who are Board Eligible (American Board of Otolaryngology) or a Fellow of the Royal College of Surgeons of Canada.

During the one year fellowship, Fellows will gain experience in both Head and Neck Oncologic Surgery and Skull Base Surgery.   The Head and Neck Oncology component will be supervised by Dr. Martin Corsten, and will consist of clinical and operative exposure to mucosal Head and Neck Cancer, salivary gland malignancies, head and neck melanoma, and thyroid pathology.   The Skull Base Surgery component will be supervised by Dr. Martin Corsten and Dr. Amin Kassam, and will consist of exposure to both Endoscopic Endonasal Approaches to the skull base as well as conventional open skull base approaches.   The Fellow will have an opportunity to learn the intricacies of skull base anatomy from both the dorsal and ventral perspectives.  The 360o Cranial Base Laboratory is equipped with state-of the-art microscopic and endoscopic cadaveric dissection stations that are augmented with powerful imaging and navigation platforms.  Fellows will master both conventional and endoscopic endonasal skull base approaches by observing them in the operating rooms and then performing them on cadaveric specimens in the laboratory.  Subsequently, Fellows will be immersed in the high-volume clinical Head and Neck Oncology and Skull Base service where they will function as junior staff members.

The fellowship program is academically oriented. Research projects with focus on Head and Neck Oncology and Skull Base Surgery are encouraged and supported. Fellows are expected to submit at least two manuscripts for publication annually. Fellows are also encouraged to submit abstracts for major national and international meetings.

Unique Features

1) Exposure to full range of Head and Neck Oncology.

2) Comprehensive approach to minimally invasive skull base surgery: the goal is not to promote one approach over the other; instead, the Fellow will gain excellent experience in both conventional and endoscopic approaches.

3) Easy and encouraged access to the 360 Cranial Base Laboratory

4) The spirit of collegiality nurtured by our team. We “listen” to and “learn” from our fellows as much (if not more) than they “listen” and ” learn” from us.

5) Innovation is welcomed and encouraged by each of our team members.

Fellowship Objectives

Objectives of Fellowship

•                     To gain sufficient clinical experience in Head and Neck Oncology, including exposure to multi-disciplinary clinical conferences on Head and Neck Cancer lesions.

•                     To gain sufficient clinical experience in complex Skull Base surgery; both conventional and endoscopic.

•         To actively participate in Head and Neck Oncology and Skull Base research.

•         To have the opportunity to publish and establish expertise in the areas above, to prepare for an academic career and consultative service in this subspecialty.

Eligibility and Qualifications

The candidate should be a Board Eligible Otolaryngologist – Head and Neck Surgeon  (American Board of Otolaryngology) or a Fellow of the Royal College of Surgeons of Canada) who is eligible for a Wisconsin medical license. Non US citizens must be eligible for an H1-B visa.

Stipends and Benefits

The ANI offers a highly competitive compensation package. Details will be discussed during the interview.

Selection Process

Eligible applicants should direct their CVs and letter of intent to the fellowship program director. The letter of intent should specify the desired start date. Competitive  applicants will be invited for an interview. Applicants are evaluated on the basis of their academic standing, research productivity, letters of references, future goals and objectives.

For more information visit us at:

Www.aurora.org/ANII or

http://www.aurorahealthcare.org/services/neurology-neurosurgery/neuroscience-innovation-institute

New Clinical Trial:Minimally Invasive Surgery Plus rt-PA for ICH Evacuation Phase III (MISTIE III)

See All Stroke Trials

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, is looking for individuals to participate in clinical studies.  Participating in clinical trials allows you to play an active role in research on the nature and causes of many disorders of the brain and nervous system, and to possibly help physician-scientists develop future treatments.  The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible.

Description:

The purpose of this study is to test a minimally invasive surgical procedure with a drug called rt-PA (recombinant tissue plasminogen activator) as a treatment for intracerebral hemorrhage (ICH).

ICH occurs when a blood vessel in part of the brain bursts open, causing blood to leak into the brain and clot.  Currently, there is no standard treatment for ICH and most people with ICH face a long recovery and have long term deficits.

MISTIE III will test a minimally invasive surgical procedure in which a hollow tube, called a catheter, is used to remove the blood clot and administer rt-PA into the ICH to break up the blood clot.  Rt-PA is the standard treatment for ischemic stroke (a type of stroke in which a blood vessel is blocked by a clot).

Five hundred participants will be randomly assigned to one of two groups:  medical treatment or surgical treatment.  In the medical group, participants will receive standard medical interventions for treating ICH.  In the surgical group, participants will undergo a minimally invasive surgical procedure to put in place a catheter that will be used to administer rt-PA directly into the blood clot.  After being assigned to a study group, participants will be monitored in the hospital for seven days.  During this time, the medical group will receive the best currently available ICH treatments.  The surgical group will receive up to 9 doses of rt-PA through the catheter every eight hours plus the same care the medical group receives.  Both groups will have daily computed tomography (CT) brain scans.

Participants will be followed for a year after their ICH to determine if the surgical procedure and rt-PA will help them to recover more fully.  Follow-up will include three outpatient visits to the clinic and two telephone interviews.

Knowledge gained from this study may provide scientists with information on how to better treat ICH.

 

Eligibility Criteria:

Please follow this link for trial eligibility information to share with your doctor.

Study Design:

Interventional

Study Locations:

Multiple locations worldwide

For more information:

Contact:  Amanda Bistran-Hall; Tel: 410-955-2536, email:  abistran1@jhmi.edu; or Karen Lane, CMA; Tel: 410-614-3461; email: klane@jhmi.edu; or visit: http://clinicaltrials.gov/ct2/show/NCT01827046 orwww.braininjuryoutcomes.com External link