Resective epilepsy surgery

Resective epilepsy surgery

Resective epilepsy surgery based on an invasive EEG-monitors performed with subdural grids (SDG) or depth electrodes (stereoelectroencephalographySEEG) is considered to be the best option towards achieving seizure-free state in drug resistant epilepsy.

Despite good outcomes from high-quality clinical trials, referrals of patients with seizures refractory to medical treatment remain infrequent 1).

Three RCTs (two adult RCTs and one pediatric RCT) consistently supported the efficacy of resective surgery as treatment for epilepsy with semiology localized to the mesial temporal lobe. In these studies, 58-100% of the patients who underwent resective surgery achieved seizure freedom, in comparison to 0-13% of medically treated patients. In another RCT, the likelihood of seizure freedom after resective surgery was independent of the surgical approach (transSylvian [64%] versus subtemporal [62%]). Two other RCTs demonstrated that hippocampal resection is essential to optimize seizure control. But, no significant gain in seizure control was achieved beyond removing 2.5 cm of the hippocampus. Across RCTs, minor complications (deficit lasting < 3 months) and major complications (deficit > 3 months) ranged 2-5% and 5-11% respectively. However, nonincapacitating superior subquadrantic visual-field defects (not typically considered a minor or major complication) were noted in up to 55% of the surgical cohort. The available RCTs provide compelling support for resective surgery as a treatment for mesial temporal lobe epilepsy and offer insights toward optimal surgical strategy 2)

Complete removal of the epileptogenic zone significantly increases the chances for postoperative seizure-freedom. In complex surgical candidates, delineation of the epileptogenic zone requires a long-term invasive video/EEG from intracranial electrodes. It is especially challenging to achieve a complete resection in deep brain structures such as opercular insular cortex 3).

Belohlavkova et al. retrospectively reviewed data of pediatric patients operated in Motol Epilepsy Center between October 2010 and June 2020 who underwent resections guided by intraoperative visual detection of depth electrodes following SEEG. The outcome in terms of seizure- and AED-freedom was assessed individually in each patient.

Nineteen patients (age at surgery 2.9-18.6 years, median 13 years) were included in the study. The epileptogenic zone involved opercular insular cortex in eighteen patients. The intraoperative detection of the electrodes was successful in seventeen patients and the surgery was regarded complete in sixteen. Thirteen patients were seizure-free at final follow-up including six drug-free cases. The successful intraoperative detection of the electrodes was associated with favorable outcome in terms of achieving complete resection and seizure-freedom in most cases. On the contrary, the patients in whom the procedure failed had poor postsurgical outcome.

The reported technique helps to achieve the complete resection in challenging patients with the epileptogenic zone in deep brain structures 4)


81 patients with tuberous sclerosis complex (TSC) who had undergone resective epilepsy surgery at Sanbo Brain Hospital, between April 2004 and June 2019. They estimated the cumulative probability of remaining seizure-free and plotted survival curves. Variables were compared using Mann-Whitney U, Pearson’s correlation, continuity correction, and Fisher’s exact chi-square tests. Prognostic predictors were analyzed using log-rank (Mantel-Cox) tests and Cox regression models.

At the last follow-up, 48 (59.3%) patients were classified as International League Against Epilepsy Class 1 (including 14 patients who had seizures <3 times postoperatively on the same or different day and were seizure-free at all other times). The estimated cumulative probability of remaining seizure-free postoperatively was 69.0% (95% confidence interval [CI] 58.8-79.2%), 61.9% (95% CI 51.1-72.7%), and 55.0% (95% CI 42.8-67.2%) at 2, 5, and 10 years, respectively. The mean time of remaining seizure-free was 7.24 ± 0.634 years (95% CI 6.00-8.49); en bloc resection was an essential positive predictor of postoperative seizure freedom, as was age at seizure onset, regional interictal video-electroencephalography pattern, and temporal lobe surgery. The longer the seizure-free time, the less likely a relapse. Patients who postoperatively experienced seizures remained likely to recover.

They demonstrated the efficacy of tuberous sclerosis complex treatment and intractable epilepsy with surgery. Detailed perioperative tests are a reliable predictor of postoperative seizure freedom 5)


1)

Jobst BC, Cascino GD. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. JAMA. 2015 Jan 20;313(3):285-93. doi: 10.1001/jama.2014.17426. PMID: 25602999.
2)

Cramer SW, McGovern RA, Wang SG, Chen CC, Park MC. Resective epilepsy surgery: assessment of randomized controlled trials. Neurosurg Rev. 2021 Aug;44(4):2059-2067. doi: 10.1007/s10143-020-01432-x. Epub 2020 Nov 9. PMID: 33169227.
3) , 4)

Belohlavkova A, Jahodova A, Kudr M, Benova B, Ebel M, Liby P, Taborsky J, Jezdik P, Janca R, Kyncl M, Tichy M, Krsek P. May intraoperative detection of stereotactically inserted intracerebral electrodes increase precision of resective epilepsy surgery? Eur J Paediatr Neurol. 2021 Sep 25;35:49-55. doi: 10.1016/j.ejpn.2021.09.012. Epub ahead of print. PMID: 34610561.
5)

Huang Q, Zhou J, Wang X, Li T, Wang M, Wang J, Teng P, Qi X, Zhu M, Luan G, Zhai F. Predictors and Long-term Outcome of Resective Epilepsy Surgery in Patients with Tuberous Sclerosis Complex: A Single-centre Retrospective Cohort Study. Seizure. 2021 Mar 25;88:45-52. doi: 10.1016/j.seizure.2021.03.022. Epub ahead of print. PMID:

Journal of Neurosurgery June 2017

A brief history of carotid-cavernous fistula
A method for safely resecting anterior butterfly gliomas: the surgical anatomy of the default mode network and the relevance of its preservation
A prospective randomized trial of the optimal dose of mannitol for intraoperative brain relaxation in patients undergoing craniotomy for supratentorial brain tumor resection
Prophylactic antiepileptic drug administration following brain tumor resection: results of a recent AANS/CNS Section on Tumors survey

Journal of Neurosurgery: Pediatrics March 2017

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  • Letter to the Editor: Postoperative hyponatremia

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  • Letter to the Editor: Early seizure prophylaxis in pediatric severe traumatic brain injury: still a long way to go

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  • Letter to the Editor: Cranial vault remodeling

    Miguel Gelabert-González, PhD, Eduardo Arán-Echabe, MD, and José María Santín-Amo, MDUniversity of Santiago de Compostela, Spain

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Journal of Neurosurgery: Spine March 2017

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  • Spine stereotactic radiosurgery for the treatment of multiple myeloma

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  • Malignant peripheral nerve sheath tumors of the spine: results of surgical management from a multicenter study

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  • Multiple-hook fixation in revision spinal deformity surgery for patients with a previous multilevel fusion mass: technical note and preliminary outcomes

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    Abstract | Full Text | PDF (3175 KB) | Add to Favorites

  • Bone marrow stromal cell sheets may promote axonal regeneration and functional recovery with suppression of glial scar formation after spinal cord transection injury in rats

    Akinori Okuda, MD1,2, Noriko Horii-Hayashi, PhD2, Takayo Sasagawa, MS2, Takamasa Shimizu, MD, PhD1, Hideki Shigematsu, MD, PhD1, Eiichiro Iwata, MD, PhD1, Yasuhiko Morimoto, MD1, Keisuke Masuda, MD1, Munehisa Koizumi, MD, PhD3, Manabu Akahane, MD, PhD4, Mayumi Nishi, MD, PhD2, and Yasuhito Tanaka, MD, PhD1 1Department of Orthopaedic Surgery, Nara Medical University, Kashihara; 2Department of Anatomy and Cell Biology, Faculty of Medicine, Nara Medical University, Kashihara; 3Spine and Spinal Cord Surgery Center, Nara Prefecture General Medical Center; and 4Department of Public Health, Health Management, and Policy, Nara Medical University, Kashihara, Nara, Japan

    Pages 388-395

    Abstract | Full Text | PDF (8390 KB) | Add to Favorites

  • Promotion of astrocytoma cell invasion by micro RNA–22 targeting of tissue inhibitor of matrix metalloproteinase–2

    Yu-ichiro Ohnishi, MD, PhD1, Koichi Iwatsuki, MD, PhD1, Masahiro Ishihara, MD, PhD1, Toshika Ohkawa, MD, PhD2, Manabu Kinoshita, MD, PhD3, Koei Shinzawa, PhD4, Yasunori Fujimoto, MD, PhD1, and Toshiki Yoshimine, MD, PhD1Departments of 1Neurosurgery and 4Molecular Genetics, Osaka University Medical School; 2Department of Neurosurgery, Yao Municipal Hospital; and 3Department of Neurosurgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

    Pages 396-403

    Abstract | Full Text | PDF (6269 KB) | Add to Favorites

  • FREE

    Erratum: Screening via CT angiogram after traumatic cervical spine fractures: narrowing imaging to improve cost effectiveness. Experience of a Level I trauma center

    Gabriel A. Smith, MDCase Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH

    Pages 404-404

    Citation | Full Text | PDF (598 KB) | Add to Favorites

  • Letter to the Editor: Pedicle screw–based dynamic stabilization and adjacent-segment disease

    Yu-Wen Cheng, MD1,2, Peng-Yuan Chang, MD1,2, Jau-Ching Wu, MD, PhD1,2, Chih-Chang Chang, MD1,2, Li-Yu Fay, MD1,2,3, Tsung-Hsi Tu, MD1,2,4, Wen-Cheng Huang, MD, PhD1,2, and Henrich Cheng, MD, PhD1,2,3 1Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; 2School of Medicine, National Yang-Ming University, Taipei, Taiwan; 3Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan; and 4Molecular Medicine Program, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan

    Pages 405-406
    Response

    Yu Han, MM, Jianguang Sun, MM, Shilei Huang, MM, and Guofu Pi, MM

    Citation | Full Text | PDF (1457 KB) | Add to Favorites

  • FREE

    Letter to the Editor: Screening via CT angiogram and cervical spine fractures

    Xiao Wu, BS, David Durand, MD, Vivek B. Kalra, MD, Sowmya Mahalingam, MD, and Ajay Malhotra, MD, MMMYale School of Medicine, New Haven, CT

    Pages 406-407
    Response

    Gabriel A. Smith, MD, Megan M. Lockwood, MD, and Michael P. Steinmetz, MD

    Citation | Full Text | PDF (1457 KB) | Add to Favorites

  • Letter to the Editor: Adult spinal deformity surgery: is it always worthwhile?

    Enrico Tessitore, MD, and Oliver P. Gautschi, MDUniversity Hospital Geneva, Switzerland

    Pages 408-409
    Response

    Citation | Full Text | PDF (1457 KB) | Add to Favorites

Journal of Neurosurgery March 2017

  • Foramen magnum meningiomas: surgical results and risks predicting poor outcomes based on a modified classification

    Da Li, MD1,2,3,4,, Zhen Wu, MD, PhD1,2,3,4, Cong Ren, MD1,2,3,4, Shu-Yu Hao, MD, PhD1, Liang Wang, MD, PhD1, Xin-Ru Xiao, MD, PhD1, Jie Tang, MD, PhD1, Yong-Gang Wang, MD, PhD1, Guo-Lu Meng, MD, PhD1, Li-Wei Zhang, MD, PhD1,2,3,4, and Jun-Ting Zhang, MD1,2,3,4 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases; 3Center of Brain Tumor, Beijing Institute for Brain Disorders; and 4Beijing Key Laboratory of Brain Tumor, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China

    Pages 661-676

    Abstract | Full Text | PDF (11357 KB) | Add to Favorites

  • Body habitus, serum albumin, and the outcomes after craniotomy for tumor: a National Surgical Quality Improvement Program analysis

    Hormuzdiyar H. Dasenbrock, MD1,2, Kevin X. Liu, DPhil2, Vamsidhar Chavakula, MD1,2, Christopher A. Devine, MPhil2, William B. Gormley, MD, MPH1,2, Elizabeth B. Claus, PhD, MD1,2,3, Timothy R. Smith, MD, PhD, MPH1,2, and Ian F. Dunn, MD1,2 1Department of Neurosurgery, Brigham and Women’s Hospital; 2Harvard Medical School, Boston, Massachusetts; and 3School of Public Health, Yale University, New Haven, Connecticut

    Pages 677-689

    Abstract | Full Text | PDF (2504 KB) | Add to Favorites

  • Preoperative diagnosis of vagal and sympathetic cervical schwannomas based on radiographic findings

    Christopher S. Graffeo, MD1, Kathryn M. Van Abel, MD2, Jonathan M. Morris, MD3, Matthew L. Carlson, MD2, Jamie J. Van Gompel, MD1, Eric J. Moore, MD2, Daniel L. Price, MD2, Jan L. Kasperbauer, MD2, Jeffrey R. Janus, MD2, Kerry D. Olsen, MD2, and Michael J. Link, MD1Departments of 1Neurologic Surgery, 2Otolaryngology–Head and Neck Surgery, and 3Radiology, Mayo Clinic, Rochester, Minnesota

    Pages 690-697

    Abstract | Full Text | PDF (3674 KB) | Supplemental Material | Add to Favorites

  • Functional approach using intraoperative brain mapping and neurophysiological monitoring for the surgical treatment of brain metastases in the central region

    Jose L. Sanmillan, MD1, Alejandro Fernández-Coello, MD1, Isabel Fernández-Conejero, MD2, Gerard Plans, MD1, and Andreu Gabarrós, MD, PhD1Departments of 1Neurosurgery and 2Neurophysiology, Hospital Universitari de Bellvitge, Barcelona, Spain

    Pages 698-707

    Abstract | Full Text | PDF (5181 KB) | Add to Favorites

  • Quality of life is maintained using Gamma Knife radiosurgery: a prospective study of a brain metastases patient cohort

    Bente Sandvei Skeie, MD, PhD1,2, Geir Egil Eide, PhD5,6, Marianne Flatebø1, Jan Ingeman Heggdal, MSc4, Elisabeth Larsen1, Sidsel Bragstad, MSc1, Paal-Henning Pedersen, MD, PhD1,2, and Per Øyvind Enger, MD, PhD1,3Departments of 1Neurosurgery and 4Oncology and Medical Physics, and 6Centre for Clinical Research, Haukeland University Hospital; and Departments of 2Clinical Medicine, 3Biomedicine, Oncomatrix Research Lab, and 5Global Public Health and Primary Care, University of Bergen, Norway

    Pages 708-725

    Abstract | Full Text | PDF (6508 KB) | Add to Favorites

  • BRAF V600E mutation and BRAF kinase inhibitors in conjunction with stereotactic radiosurgery for intracranial melanoma metastases

    Zhiyuan Xu, MD1, Cheng-Chia Lee, MD1,3,4, Arjun Ramesh, MD1, Adam C. Mueller, MD, PhD2, David Schlesinger, PhD1,2, Or Cohen-Inbar, MD, PhD1, Han-Hsun Shih, MD5, and Jason P. Sheehan, MD, PhD1,2Departments of 1Neurological Surgery and 2Radiation Oncology, University of Virginia, Charlottesville, Virginia; 3Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital; 4School of Medicine, National Yang-Ming University, Taipei; and 5Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China

    Pages 726-734

    Abstract | Full Text | PDF (2626 KB) | Add to Favorites

  • Impact of the radiosurgery prescription dose on the local control of small (2 cm or smaller) brain metastases

    Alireza M. Mohammadi, MD1,2, Jason L. Schroeder, MD5, Lilyana Angelov, MD1,2, Samuel T. Chao, MD3, Erin S. Murphy, MD3, Jennifer S. Yu, MD, PhD3, Gennady Neyman, PhD3, Xuefei Jia, MS4, John H. Suh, MD3, Gene H. Barnett, MD1,2, and Michael A. Vogelbaum, MD, PhD1,2 1The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Departments of 2Neurosurgery and 3Radiation Oncology, and 4Quantitative Health Science, Neurological Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland; and 5Department of Neurosurgery, University of Toledo Medical Center, Toledo, Ohio

    Pages 735-743

    Abstract | Full Text | PDF (2001 KB) | Add to Favorites

  • Stereotactic radiosurgery for intracranial hemangiopericytomas: a multicenter study

    Or Cohen-Inbar, MD, PhD1, Cheng-Chia Lee, MD2, Seyed H. Mousavi, MD3, Hideyuki Kano, MD, PhD3, David Mathieu, MD4, Antonio Meola, MD3, Peter Nakaji, MD5, Norissa Honea, PhD5, Matthew Johnson, MD6, Mahmoud Abbassy, MD7, Alireza M. Mohammadi, MD7, Danilo Silva, MD7, Huai-Che Yang, MD2, Inga Grills, MD6, Douglas Kondziolka, MD, MSc8, Gene H. Barnett, MD8, L. Dade Lunsford, MD3, and Jason Sheehan, MD, PhD1 1Department of Neurosurgery and Gamma Knife Center, University of Virginia Health System, Charlottesville, Virginia; 3Department of Neurosurgery, University of Pittsburgh, Pennsylvania; 5Department of Neurosurgery, Barrow Neurological Institute and St. Joseph’s Hospital and Medical Center, Phoenix, Arizona; 6Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan; 7Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio; 8Department of Neurosurgery, New York University Langone Medical Center, New York, New York; 2Neurological Institute, Taipei Veterans General Hospital, and National Yang-Ming University, Taipei, Taiwan; and 4Department of Neurosurgery, University of Sherbrooke, Centre de Recherche Clinique Étienne-LeBel, Sherbrooke, Quebec, Canada

    Pages 744-754

    Abstract | Full Text | PDF (2951 KB) | Add to Favorites

  • Factors predicting contralateral hematoma growth after unilateral drainage of bilateral chronic subdural hematoma

    Shigeta Fujitani, MD1, Osamu Ishikawa, MD, PhD2, Keisuke Miura, MD1, Yasuhiro Takeda, MD1, Haruo Goto, MD1, and Keiichiro Maeda, MD, PhD1 1Department of Neurosurgery, Aizu Chuo Hospital, Aizuwakamatsu, Fukushima; and 2Department of Neurosurgery, Showa General Hospital, Kodaira, Tokyo, Japan

    Pages 755-759

    Abstract | Full Text | PDF (1891 KB) | Add to Favorites

  • Impact of Glasgow Coma Scale score and pupil parameters on mortality rate and outcome in pediatric and adult severe traumatic brain injury: a retrospective, multicenter cohort study

    Pedram Emami, MD1,, Patrick Czorlich, MD1, Friederike S. Fritzsche, MD1, Manfred Westphal, MD1, Johannes M. Rueger, MD2, Rolf Lefering, PhD3, and Michael Hoffmann, MD2Departments of 1Neurosurgery and 2Trauma, Hand, and Reconstructive Surgery, University Medical Center Hamburg-Eppendorf, Hamburg; and 3Institute for Research in Operative Medicine, Witten/Herdecke University, Cologne, Germany

    Pages 760-767

    Abstract | Full Text | PDF (1998 KB) | Add to Favorites

  • Helmet efficacy against concussion and traumatic brain injury: a review

    Je Yeong Sone1, Douglas Kondziolka, MD, MSc1, Jason H. Huang, MD2, and Uzma Samadani, MD, PhD3 1Department of Neurosurgery, New York University School of Medicine, New York, New York; 2Department of Neurosurgery, Baylor Scott & White Central Division, Temple, Texas; and 3Department of Neurosurgery, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota

    Pages 768-781

    Abstract | Full Text | PDF (6933 KB) | Add to Favorites

  • Treatment of traumatic brain injury in rats with N-acetyl-seryl-aspartyl-lysyl-proline

    Yanlu Zhang, MD1, Zheng Gang Zhang, MD, PhD2, Michael Chopp, PhD2,3, Yuling Meng, PhD1, Li Zhang, MD2, Asim Mahmood, MD1, and Ye Xiong, MD, PhD1Departments of 1Neurosurgery and 2Neurology, Henry Ford Hospital, Detroit; and 3Department of Physics, Oakland University, Rochester, Michigan

    Pages 782-795

    Abstract | Full Text | PDF (17755 KB) | Add to Favorites

  • Traumatic hemorrhagic brain injury: impact of location and resorption on cognitive outcome

    Ryan M. Martin, MD1,2, Matthew J. Wright, PhD3, Evan S. Lutkenhoff, PhD4, Benjamin M. Ellingson, PhD, MS5, John D. Van Horn, PhD6, Meral Tubi, BA1, Jeffry R. Alger, PhD2, David L. McArthur, PhD, MPH1, and Paul M. Vespa, MD1,2Departments of 1Neurosurgery, 2Neurology, 3Pyschiatry & Biobehavioral Sciences, 4Psychology, and 5Radiological Sciences, University of California, Los Angeles; and 6Department of Neurology, University of Southern California, Los Angeles, California

    Pages 796-804

    Abstract | Full Text | PDF (8429 KB) | Add to Favorites

  • FREE

    Medicare expenditures for elderly patients undergoing surgical clipping or endovascular intervention for subarachnoid hemorrhage

    Kimon Bekelis, MD1,2, Daniel J. Gottlieb, MS2, Yin Su, MS2, Giuseppe Lanzino, MD3, Michael T. Lawton, MD4, and Todd A. MacKenzie, PhD2,5,6 1Section of Neurosurgery; 6Department of Medicine, Dartmouth-Hitchcock Medical Center; 2The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon; 5Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; 3Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota; and 4Department of Neurosurgery, University of California San Francisco Medical Center, San Francisco, California

    Pages 805-810

    Abstract | Full Text | PDF (2300 KB) | Supplemental Material | Add to Favorites

  • FREE

    Comparison of clipping and coiling in elderly patients with unruptured cerebral aneurysms

    Kimon Bekelis, MD1, Daniel J. Gottlieb, MS2, Yin Su, PhD2, A. James O’Malley, PhD2,3, Nicos Labropoulos, PhD4, Philip Goodney, MD, MS5,6, Michael T. Lawton, MD7, and Todd A. MacKenzie, PhD2,3,8,9Sections of 1Neurosurgery and 5Vascular Surgery; Departments of 8Medicine and 9Community and Family Medicine, Dartmouth-Hitchcock Medical Center; 2The Dartmouth Institute for Health Policy and Clinical Practice, Lebanon; 3Department of Biomedical Data Science, 6Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; 4Department of Radiology, Stony Brook University Medical Center, Stony Brook, New York; and 7Department of Neurosurgery, University of California, San Francisco Medical Center, San Francisco, California

    Pages 811-818

    Abstract | Full Text | PDF (3135 KB) | Supplemental Material | Add to Favorites

  • A long-term study of durability and risk factors for aneurysm recurrence after microsurgical clip ligation

    Mason A. Brown, BS1, Jonathan Parish, MD1, Cristian F. Guandique, BA1, Troy D. Payner, MD1, Terry Horner, MD1, Thomas Leipzig, MD1, Karishma V. Rupani, MBBCh1, Richard Kim, MD1, Bradley N. Bohnstedt, MD2, and Aaron A. Cohen-Gadol, MD, MSc1 1Goodman Campbell Brain and Spine, and Department of Neurosurgery, Indiana University, Indianapolis, Indiana; and 2Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma

    Pages 819-824

    Abstract | Full Text | PDF (1252 KB) | Add to Favorites

  • Educational and interactive informed consent process for treatment of unruptured intracranial aneurysms

    Jaechan Park, MD, PhD1,2, Wonsoo Son, MD1,2, Ki-Su Park, MD1,2, Dong-Hun Kang, MD1,2, Joomi Lee, PhD3, Chang Wan Oh, MD, PhD4, O-Ki Kwon, MD, PhD4, Taesun Kim, MD, PhD5, and Chang-Hyun Kim, MD6 1Department of Neurosurgery, 2Research Center for Neurosurgical Robotic Systems, and 3Cell & Matrix Research Institute, Kyungpook National University, Daegu; 4Department of Neurosurgery, Seoul National University College of Medicine, Seoul; 5Department of Neurosurgery, Chonnam National University Medical School, Gwangju; and 6Department of Neurosurgery, Keimyung University School of Medicine, Daegu, Republic of Korea

    Pages 825-830

    Abstract | Full Text | PDF (1281 KB) | Add to Favorites

  • White-collar sign as a predictor of outcome after endovascular treatment for cerebral aneurysms

    Kenji Fukuda, MD, Toshio Higashi, MD, PhD, Masakazu Okawa, MD, PhD, Mitsutoshi Iwaasa, MD, PhD, Tsutomu Yoshioka, MD, PhD, and Tooru Inoue, MD, PhDDepartment of Neurosurgery, Fukuoka University Hospital, and School of Medicine, Fukuoka University, Fukuoka, Japan

    Pages 831-837

    Abstract | Full Text | PDF (2111 KB) | Add to Favorites

  • Use of a surgical rehearsal platform and improvement in aneurysm clipping measures: results of a prospective, randomized trial

    A. Jessey Chugh, BS1, Jonathan R. Pace, MD2, Justin Singer, MD2, Curtis Tatsuoka, PhD3, Alan Hoffer, MD2, Warren R. Selman, MD2, and Nicholas C. Bambakidis, MD2 1Case Western Reserve University School of Medicine; and Departments of 2Neurological Surgery and 3Neurology, University Hospitals Case Medical Center, Cleveland, Ohio

    Pages 838-844

    Abstract | Full Text | PDF (9837 KB) | Add to Favorites

  • Seizure outcomes after stereotactic radiosurgery for the treatment of cerebral arteriovenous malformations

    Benjamin J. Ditty, MD, Nidal B. Omar, MD, Paul M. Foreman, MD, Joseph H. Miller, MD, Kimberly P. Kicielinski, MD, Winfield S. Fisher III, MD, and Mark R. Harrigan, MDDepartment of Neurosurgery, University of Alabama at Birmingham, Alabama

    Pages 845-851

    Abstract | Full Text | PDF (1731 KB) | Add to Favorites

  • Comparative analysis of arteriovenous malformation grading scales in predicting outcomes after stereotactic radiosurgery

    Bruce E. Pollock, MD1,2, Curtis B. Storlie, PhD3, Michael J. Link, MD1,4, Scott L. Stafford, MD2, Yolanda I. Garces, MD2, and Robert L. Foote, MD2Departments of 1Neurological Surgery, 2Radiation Oncology, 3Biomedical Statistics and Informatics, and 4Otorhinolaryngology, Mayo Clinic College of Medicine, Rochester, Minnesota

    Pages 852-858

    Abstract | Full Text | PDF (1591 KB) | Add to Favorites

  • Stereotactic radiosurgery for Spetzler-Martin Grade III arteriovenous malformations: an international multicenter study

    Dale Ding, MD1, Robert M. Starke, MD, MSc1, Hideyuki Kano, MD, PhD2, John Y. K. Lee, MD, MSCE3, David Mathieu, MD4, John Pierce, MS3, Paul P. Huang, MD5, Caleb Feliciano, MD6, Rafael Rodriguez-Mercado, MD6, Luis Almodovar, MD6, Inga S. Grills, MD7, Danilo Silva, MD8, Mahmoud Abbassy, MD8, Symeon Missios, MD8, Douglas Kondziolka, MD5, Gene H. Barnett, MD8, L. Dade Lunsford, MD2, and Jason P. Sheehan, MD, PhD1 1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia; 2Department of Neurological Surgery, University of Pittsburgh, and 3Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania; 4Division of Neurosurgery, University of Sherbrooke, Centre de recherché du CHUS, Sherbrooke, Quebec, Canada; 5Department of Neurosurgery, NYU Langone Medical Center, New York, New York; 6Section of Neurological Surgery, University of Puerto Rico, San Juan, Puerto Rico; 7Beaumont Health System, Royal Oak, Michigan; and 8Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio

    Pages 859-871

    Abstract | Full Text | PDF (2897 KB) | Add to Favorites

  • Endoscopic endonasal control of the paraclival internal carotid artery by Fogarty balloon catheter inflation: an anatomical study VIDEO

    Andrea Ruggeri, MD1, Joaquim Enseñat, PhD2, Alberto Prats-Galino, PhD3, Antonio Lopez-Rueda, MD4, Joan Berenguer, PhD4, Martina Cappelletti, MD1, Matteo De Notaris, PhD5, and Elena d’Avella, MD3,6 1Department of Neuroscience, Neurosurgery, University of Rome “Sapienza,” Rome, Italy; 2Department of Neurosurgery, Hospital Clinic, Faculty of Medicine, Universitat de Barcelona, Spain; 3Laboratory of Surgical NeuroAnatomy (LSNA), Human Anatomy and Embryology Unit, Faculty of Medicine, Universitat de Barcelona, Spain; 4Department of Radiology, Hospital Clinic, Faculty of Medicine, Universitat de Barcelona, Spain; 5Neurosurgical Department, “G. Rummo” Hospital of Benevento, Benevento, Italy; and 6Department of Neuroscience, Neurosurgery, University of Padua, Italy

    Pages 872-879

    Abstract | Full Text | PDF (9357 KB) | Add to Favorites

  • Endoscopic endonasal surgery for nonadenomatous, nonmeningeal pathology involving the cavernous sinus

    Aikaterini Patrona, MD1, Kunal S. Patel, MD2, Evan D. Bander, BA2, Alpesh Mehta, MD4, Apostolos John Tsiouris, MD4, Vijay K. Anand, MD5, and Theodore H. Schwartz, MD2,3,4 1Department of Neurosurgery, Medizinische Hochschule Brandenburg, Ruppiner Kliniken, Neuruppin, Germany; and Departments of 2Neurosurgery, 3Neuroscience, 4Radiology, and 5Otolaryngology, Weill Cornell Medical College, NewYork-Presbyterian Hospital, New York, New York

    Pages 880-888

    Abstract | Full Text | PDF (1942 KB) | Add to Favorites

  • Primary versus revision transsphenoidal resection for nonfunctioning pituitary macroadenomas: matched cohort study

    Colin J. Przybylowski, MD1, Robert F. Dallapiazza, MD, PhD1, Brian J. Williams, MD1, I. Jonathan Pomeraniec, BS1, Zhiyuan Xu, MD1, Spencer C. Payne, MD2, Edward R. Laws, MD3, and John A. Jane Jr., MD1Departments of 1Neurosurgery and 2Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia; and 3Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

    Pages 889-896

    Abstract | Full Text | PDF (1958 KB) | Add to Favorites

  • Neurosurgery and human immunodeficiency virus in the era of combination antiretroviral therapy: a review

    Duncan Henderson, BSc, MBChB1,, Hugh P. Sims-Williams, MBChB, MSc, MRCS2, Thomas Wilhelm, MD, FRCR3, Helen Sims-Williams, BMBCh, MA(Cantab), MRCP4, Sanjay Bhagani, MBChB, BSc, FRCP3, and Lewis Thorne, BSc, MBChB, FRCS5 1Plymouth Hospitals NHS Trust, Plymouth, United Kingdom; 2Sheffield Teaching Hospitals Trust, Sheffield, United Kingdom; 3Royal Free Hospital, London, United Kingdom; 4CURE Children’s Hospital of Uganda, Mbale, Uganda; and 5National Hospital for Neurology and Neurosurgery, London, United Kingdom

    Pages 897-907

    Abstract | Full Text | PDF (3013 KB) | Add to Favorites

  • Antibiotic prophylaxis for subdural and subgaleal drains

    Ariane Lewis, MD1,2, Rajeev Sen, BA3, Travis C. Hill, PhD2,3, Herbert James, BS3, Jessica Lin, MD1, Harpaul Bhamra, MD1, Nina Martirosyan, BS, PharmD4, and Donato Pacione, MD2Departments of 1Neurology and 2Neurosurgery; 3NYU School of Medicine; and 4Pharmacy, NYU Langone Medical Center, New York, New York

    Pages 908-912

    Abstract | Full Text | PDF (1275 KB) | Add to Favorites

  • Functional anatomy of the accessory nerve studied through intraoperative electrophysiological mapping

    Andrei Brînzeu, MD, MSc1,2, and Marc Sindou, MD, DSc1,3 1Neurosurgical Department, Hospital Pierre Wertheimer, University of Lyon; 3University Hospital of Saint-Etienne, France; and 2University of Medicine and Pharmacy “Victor Babes,” Timişoara, Romania

    Pages 913-921

    Abstract | Full Text | PDF (3776 KB) | Add to Favorites

  • A systematic review of outcomes of contralateral C-7 transfer for the treatment of traumatic brachial plexus injury: an international comparison

    Alexandra L. Mathews, BS1, Guang Yang, MD2, Kate Wan-Chu Chang, MA, MS3, and Kevin C. Chung, MD1 1Section of Plastic Surgery, Department of Surgery, The University of Michigan Medical School; 3Section of Plastic Surgery, Department of Surgery, The University of Michigan Health System, Ann Arbor, Michigan; and 2Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China

    Pages 922-932

    Abstract | Full Text | PDF (7840 KB) | Add to Favorites

  • A new pattern of lipomatosis of nerve: case report

    Nikhil K. Prasad, MBChB1, Mark A. Mahan, MD3, Benjamin M. Howe, MD2, Kimberly K. Amrami, MD2, and Robert J. Spinner, MD1Departments of 1Neurologic Surgery and 2Radiology, Mayo Clinic, Rochester, Minnesota; and 3Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah

    Pages 933-937

    Abstract | Full Text | PDF (3754 KB) | Add to Favorites

  • Struthers’ ligament and traumatic median nerve injury: case illustration

    Paule Lessard Bonaventure, MD, and Hélène T. Khuong, MDDepartment of Neurological Sciences, Division of Neurosurgery, CHU de Québec–Université Laval, Québec, Canada

    Pages 938-939

    Citation | Full Text | PDF (2189 KB) | Add to Favorites

  • Contralateral supraorbital keyhole approach to medial optic nerve lesions: an anatomoclinical study

    Harminder Singh, MD1,, Walid I. Essayed, MD2, Ajit Jada, MD2, Nelson Moussazadeh, MD2,3, Sivashanmugam Dhandapani, MD4, Sarang Rote, MCh2, and Theodore H. Schwartz, MD2 1Department of Neurosurgery, Stanford University School of Medicine, Stanford, California; Department of 2Neurosurgery, Weill Cornell Medical College, NewYork-Presbyterian; 3Division of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; and 4Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Pages 940-944

    Abstract | Full Text | PDF (5407 KB) | Add to Favorites

  • FREE

    The white matter tracts of the cerebrum in ventricular surgery and hydrocephalus

    Abuzer Güngör, MD1, Serhat Baydin, MD1, Erik H. Middlebrooks, MD2,,3, Necmettin Tanriover, MD4, Cihan Isler, MD4, and Albert L. Rhoton Jr., MD1Departments of 1Neurosurgery and 2Radiology, and the 3K. Scott and E. R. Andrew Advanced Neuroimaging Lab, College of Medicine, University of Florida, Gainesville, Florida; and 4Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey

    Also appears in:
    Collections, December 2015, Volume 123, Issue 6

    Pages 945-971

    Abstract | Full Text | PDF (40189 KB) | Add to Favorites

  • The lateral femoral cutaneous nerve canal

    Amgad Hanna, MDDepartment of Neurological Surgery, University of Wisconsin, Madison, Wisconsin

    Pages 972-978

    Abstract | Full Text | PDF (14118 KB) | Add to Favorites

  • The angular course of the median nerve in the distal forearm and its anatomical importance in preventing nerve injury in a modern era of carpal tunnel release VIDEO

    Russell Payne, MD1, Zeinab Nasralah, MS2, Emily Sieg, MD1, Elias B. Rizk, MD, MSc1, Michael Glantz, MD1, and Kimberly Harbaugh, MD1Departments of 1Neurosurgery and 2Ophthalmology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

    Pages 979-984

    Abstract | Full Text | PDF (2965 KB) | Add to Favorites

  • A novel miniature robotic guidance device for stereotactic neurosurgical interventions: preliminary experience with the iSYS1 robot

    Georgi Minchev, MD1, Gernot Kronreif, PhD2, Mauricio Martínez-Moreno, MD1, Christian Dorfer, MD1, Alexander Micko, MD1, Aygül Mert, MD1, Barbara Kiesel, MD1, Georg Widhalm, MD, PhD1, Engelbert Knosp, MD1, and Stefan Wolfsberger, MD1 1Department of Neurosurgery, Medical University of Vienna, Vienna; and 2Austrian Center of Medical Innovation and Technology, Wiener Neustadt, Austria

    Pages 985-996

    Abstract | Full Text | PDF (10375 KB) | Add to Favorites

  • Novel technique of a multifunctional electrosurgical system for minimally invasive surgery

    David Mittelstein, BS1, Jiahan Deng, MS2, Rachel Kohan, BS2, Mojdeh Sadeghi, MS2, Jean-Michel Maarek, PhD2, and Gabriel Zada, MD, MS1 1Department of Neurosurgery, Keck School of Medicine, and 2Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California

    Pages 997-1002

    Abstract | Full Text | PDF (6416 KB) | Add to Favorites

  • Avoiding pullout complications in external ventricular drains: technical note

    Carlos Velásquez, MD1, Mónica Rivero-Garvía, MD, PhD2, Maria Jose Mayorga-Buiza, MD, PhD3, María de los Ángeles Cañizares-Méndez, MD4, Manuel E. Jiménez-Mejías, MD, PhD5, and Javier Márquez-Rivas, MD, PhD2 1Department of Neurological Surgery and Spine Unit, Hospital Universitario Marqués de Valdecilla and Fundación Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander; 2Department of Neurosurgery, 3Department of Pediatric Anesthesia, and 5Infectious Disease Unit, Hospitales Universitarios Virgen del Rocio, Seville; and 4Department of Neurosurgery, Complejo Hospitalario de Toledo, Spain

    Pages 1003-1005

    Abstract | Full Text | PDF (2496 KB) | Add to Favorites

  • Language pathway tracking: comparing nTMS-based DTI fiber tracking with a cubic ROIs-based protocol

    Chiara Negwer, MD1,2, Nico Sollmann, MD1,2, Sebastian Ille, MD1,2, Theresa Hauck1,2, Stefanie Maurer1,2, Jan S. Kirschke, MD3, Florian Ringel, MD1, Bernhard Meyer, MD1, and Sandro M. Krieg, MD, MBA1,2 1Department of Neurosurgery, 2TUM-Neuroimaging Center, and 3Section of Neuroradiology, Department of Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany

    Pages 1006-1014

    Abstract | Full Text | PDF (5294 KB) | Add to Favorites

  • FREE

    Erratum: Foramen magnum meningiomas: surgical results and risks predicting poor outcomes based on a modified classification

    Jun-Ting Zhang, MDBeijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China

    Pages 1017-1017

    Citation | Full Text | PDF (601 KB) | Add to Favorites

  • FREE

    Erratum: The lateral femoral cutaneous nerve canal

    Gillian ShasbyDirector of Publications–Operations, Journal of Neurosurgery Publishing Group, Charlottesville, VA

    Pages 1018-1019

    Citation | Full Text | PDF (6148 KB) | Add to Favorites

  • Letter to the Editor: Dural arteriovenous fistula: a clinical model of thalamic dementia?

    Rodrigo Carrasco, MD, and José M. Pascual, MD, PhDRamón y Cajal University Hospital, Madrid, Spain; and La Princesa University Hospital, Madrid, Spain

    Pages 1020-1022
    Response

    Gregory J. Zipfel, MD

    Citation | Full Text | PDF (5934 KB) | Add to Favorites

  • Letter to the Editor: Endoscopic transsphenoidal pituitary surgery

    Chih-Chang Chang, MD1,2, Yu-Shu Yen, MD1,2, Tsung-Hsi Tu, MD1,2,3, Li-Yu Fay, MD1,2, Wen-Cheng Huang, MD, PhD1,2, and Jau-Ching Wu, MD, PhD1,2 1Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; 2School of Medicine, National Yang-Ming University, Taipei, Taiwan; and 3Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan

    Pages 1022-1023
    Response

    Jens Conrad, MD

    Citation | Full Text | PDF (5934 KB) | Add to Favorites

  • Letter to the Editor: Role of mutational status of GNAQ and GNA11 in the diagnosis of melanocytic tumors

    Yislenz Narváez-Martínez, MD, MPH, Marc Sagristà-Garcia, MD, and Maria Teresa Fernandez-Figueras, MD, PhDUniversitary Hospital of Girona Dr. Josep Trueta, Girona, Catalonia, Spain; Sant Jaume of Calella Hospital, Calella, Catalonia, Spain; and Universitary Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain

    Pages 1024-1026
    Response

    Klaus G. Griewank, MD, Christian Koelsche, MD, Frederik Wenz, MD, Frank A. Giordano, MD, andChristoffer Gebhardt, MD

    Citation | Full Text | PDF (5934 KB) | Add to Favorites

  • Letter to the Editor: Beta-blocker therapy

    Ambuj Kumar, MS, Amandeep Kumar, MCh, Pankaj Kumar Singh, MCh, Shashwat Mishra, MCh, Kanwaljeet Garg, MCh, and Bhawani S. Sharma, MChAll India Institute of Medical Sciences, New Delhi, India

    Pages 1026-1027
    Response

    Citation | Full Text | PDF (5934 KB) | Add to Favorites

Journal of Neurosurgery February 2017

Responses to ARUBA: a systematic review and critical analysis for the design of future arteriovenous malformation trials

Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms

Fracture and migration of a retained wire into the thoracic cavity after endovascular neurointervention: report of 2 cases

Endovascular therapy of low– and intermediate-grade intracranial lateral dural arteriovenousfistulas: a detailed analysis of primary success rates, complication rates, and long-termfollow-up of different technical approaches
Racial disparities in the diagnosis and management of trigeminal neuralgia

Journal of Neurosurgery: January 2017

A randomized controlledtrial comparing autologous cranioplasty with custom-made titanium cranioplasty.
Clinical implications of the cortical hyperintensity belt sign in fluid-attenuated inversion recovery images after bypass surgery for moyamoya disease
Presentation and management of lateral sinus thrombosis following posterior fossa surgery
The impact of hybrid neurosurgeons on the outcomes of endovascular coiling for unruptured cerebral aneurysms
Stereotactic radiosurgery for cerebral arteriovenous malformations: evaluation of long-term outcomes in a multicenter cohort

Journal of Neurosurgery Pediatrics December 2016

Graded aerobic treadmill testing in pediatric sports-related concussion: safety, clinical use, and patient outcomes
Endoscopic third ventriculostomy with choroid plexus cauterization outcome: distinguishing success from failure
Normative ranges of anthropometric cranial indices and metopic suture closure during infancy
Endoscope-assisted management of sagittal synostosis: wide vertex suturectomy and barrel stave osteotomies versus narrow vertex suturectomy
In situ repair of vagus nerve stimulator lead damage: technical note
Presurgical evaluation of pediatric epilepsy patients prior to hemispherotomy: the prognostic value of 18F-FDG PET
Endoscopic posterior interhemispheric complete corpus callosotomy
Recurrent giant cranial desmoid tumor in a 3-year-old boy with familial adenomatous polyposis requiring bifrontoparietal cranioplasty: case report
Mature salivary gland rests within sonic hedgehog-positive medulloblastoma: case report and insights into the molecular genetics and embryopathology of ectopic intracranial salivary gland analogs
Thoracic osteomyelitis and epidural abscess formation due to cat scratch disease: case report
Surgical outcomes of Majewski osteodysplastic primordial dwarfism Type II with intracranial vascular anomalies
Pediatric neurosurgery telemedicine clinics: a model to provide care to geographically underserved areas of the United States and its territories

Journal of Neurosurgery Spine December 2016

A revolution in preventing fatal craniovertebral junction injuries: lessons learned from the Head and Neck Support device in professional auto racing
Minimally invasive atlantoaxial fusion: cadaveric study and report of 5 clinical cases
Venous air embolus during prone cervical spine fusion: case report
Spontaneous cerebrospinal fluid leak from an anomalous thoracic nerve root: case report

Journal of Neurosurgery December 2016

Clipping of previously coiled cerebral aneurysms: efficacy, safety, and predictors in a cohort of 111 patients
Analysis of the surgical benefits of 5-ALA–induced fluorescence in intracranial meningiomas: experience in 204 meningiomas
Aneurysm growth and de novo aneurysms during aneurysm surveillance
Association of nosocomial infections with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage
Clinical characteristics and outcome of aneurysmal subarachnoid hemorrhage with intracerebral hematoma
Intraoperative middle cerebral artery pressure measurements during superficial temporal artery to middle cerebral artery bypass procedures in patients with cerebral atherosclerotic disease
MicroRNA and gene expression changes in unruptured human cerebral aneurysms
Pipeline Embolization Device for small paraophthalmic artery aneurysms with an emphasis on the anatomical relationship of ophthalmic artery origin and aneurysm
Quality of life in patients with right- or left-sided brain tumours: literature review
Transulcal parafascicular minimally invasive approach to deep and subcortical cavernomas: technical note